Browse results for vesicle type: Extracellular vesicles

	Vesiclepedia ID	PubMed ID	Species	Experiment description	Sample	Identifications	Isolation methods	Vesicle type	MISEV
1	Vesiclepedia_1559	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
2	Vesiclepedia_1577	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
3	Vesiclepedia_2725	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
4	Vesiclepedia_3357	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Plasma	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
5	Vesiclepedia_3103	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
6	Vesiclepedia_2316	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	T cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
7	Vesiclepedia_1628	34012515	Homo sapiens	CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells	Melanoma cells	Protein Lipid	Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
8	Vesiclepedia_2842	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
9	Vesiclepedia_1882	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
10	Vesiclepedia_3249	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
11	Vesiclepedia_1745	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
12	Vesiclepedia_3235	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
13	Vesiclepedia_1572	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
14	Vesiclepedia_1057	30035390	Mus musculus	Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles.	Mouse embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
15	Vesiclepedia_3377	36581870	Mus musculus	Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Qiagen Exosome Purification Kit	Extracellular vesicles	EVs
16	Vesiclepedia_1421	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
17	Vesiclepedia_463	22849433	Homo sapiens	Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types.	Embryonic kidney cells	miRNA	-	Extracellular vesicles	EVs
18	Vesiclepedia_3236	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
19	Vesiclepedia_2389	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
20	Vesiclepedia_996	24392111	Mus musculus	Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?	Murine myoblast	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
21	Vesiclepedia_2901	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Pancreatic cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
22	Vesiclepedia_1401	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation	Extracellular vesicles	Small EVs
23	Vesiclepedia_3534	31002856	Homo sapiens	Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer	Plasma	mtDNA	Exosome Isolation Kit	Extracellular Vesicles	EVs
24	Vesiclepedia_3392	31827089	Lactobacillus crispatus	Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues	Lactobacillus crispatus	Protein Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
25	Vesiclepedia_2382	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
26	Vesiclepedia_2067	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
27	Vesiclepedia_1579	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	ProteinmRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
28	Vesiclepedia_2106	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
29	Vesiclepedia_1845	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Colorectal cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
30	Vesiclepedia_1899	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
31	Vesiclepedia_2407	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Myoblasts	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
32	Vesiclepedia_2682	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
33	Vesiclepedia_2014	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
34	Vesiclepedia_2504	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
35	Vesiclepedia_3242	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
36	Vesiclepedia_2822	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein mRNA miRNA tRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
37	Vesiclepedia_2307	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
38	Vesiclepedia_1032	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	exoEasy columns	Extracellular vesicles	EVs
39	Vesiclepedia_1395	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein Lipid	Differential centrifugation Tangential flow filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
40	Vesiclepedia_2528	34315885	Mus musculus	Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease	Kidney epithelial cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
41	Vesiclepedia_1715	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
42	Vesiclepedia_2803	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
43	Vesiclepedia_1736	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
44	Vesiclepedia_3499	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
45	Vesiclepedia_2131	36515353	Homo sapiens	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	Plasma	Metabolite Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
46	Vesiclepedia_3464	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
47	Vesiclepedia_552	24009898	Mus musculus	Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.	Cardiomyocytes	mRNA	-	Exosomes/Extracellular vesicles	EVs
48	Vesiclepedia_2314	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	T cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
49	Vesiclepedia_2807	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
50	Vesiclepedia_2081	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
51	Vesiclepedia_2952	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
52	Vesiclepedia_1590	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugation	Extracellular vesicles	Large EVs
53	Vesiclepedia_1272	24058411	Homo sapiens	Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
54	Vesiclepedia_950	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
55	Vesiclepedia_3240	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
56	Vesiclepedia_2867	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
57	Vesiclepedia_1762	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
58	Vesiclepedia_1750	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
59	Vesiclepedia_1396	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein Lipid	Differential centrifugation Tangential flow filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
60	Vesiclepedia_933	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Bladder cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
61	Vesiclepedia_1212	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultracentrifugation	Extracellular vesicles	EVs
62	Vesiclepedia_1131	23954818	Homo sapiens	Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.	Squamous carcinoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
63	Vesiclepedia_1626	34012515	Homo sapiens	CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells	Melanoma cells	Protein	Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
64	Vesiclepedia_3298	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
65	Vesiclepedia_3253	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
66	Vesiclepedia_2431	29320704	Homo sapiens	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise	Plasma	Protein	Centrifugation	Extracellular vesicles	EVs
67	Vesiclepedia_2400	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
68	Vesiclepedia_2158	34140472	Ixodes scapularis	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Ixodes scapularis	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
69	Vesiclepedia_1911	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
70	Vesiclepedia_1310	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
71	Vesiclepedia_2894	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
72	Vesiclepedia_1041	27770278	Homo sapiens	Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.	Glioblastoma cells	Protein	Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation	Extracellular vesicles	EVs
73	Vesiclepedia_2800	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
74	Vesiclepedia_2855	33579909	Homo sapiens	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
75	Vesiclepedia_2117	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
76	Vesiclepedia_3239	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
77	Vesiclepedia_3505	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
78	Vesiclepedia_2892	28928431	Mus musculus	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90	Lung cancer cells	Protein	Centrifugal ultrafiltration ExoQuick Kit	Extracellular vesicles	EVs
79	Vesiclepedia_470	23029346	Fasciola hepatica	Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells.	Fasciola hepatica	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
80	Vesiclepedia_2136	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
81	Vesiclepedia_2101	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
82	Vesiclepedia_1927	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
83	Vesiclepedia_2007	35979935	Homo sapiens	Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients	Serum	Protein Lipid	Differential centrifugation	Extracellular vesicles	EVs
84	Vesiclepedia_1792	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
85	Vesiclepedia_2018	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Centrifugation	Large extracellular vesicles	Large EVs
86	Vesiclepedia_2575	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
87	Vesiclepedia_3196	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
88	Vesiclepedia_3289	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
89	Vesiclepedia_1553	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Large EVs
90	Vesiclepedia_2548	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
91	Vesiclepedia_891	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
92	Vesiclepedia_1864	35931686	Homo sapiens	Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression	Chondrocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
93	Vesiclepedia_1102	24408433	Prochlorococcus marinus	Bacterial vesicles in marine ecosystems.	Prochlorococcus marinus	Lipids	Ultrafiltration Density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
94	Vesiclepedia_2310	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Natural killer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
95	Vesiclepedia_1939	36193887	Homo sapiens	Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
96	Vesiclepedia_3036	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
97	Vesiclepedia_2687	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein	EVtrap	Extracellular vesicles	Small EVs
98	Vesiclepedia_3231	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
99	Vesiclepedia_1129	23954818	Homo sapiens	Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.	Squamous carcinoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
100	Vesiclepedia_2570	35260554	Homo sapiens	Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis	Gastric cancer cells	Protein	Centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
101	Vesiclepedia_2817	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
102	Vesiclepedia_1387	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
103	Vesiclepedia_2888	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
104	Vesiclepedia_1254	24468161	Homo sapiens	Molecular characterization of exosome-like vesicles from breast cancer cells.	Breast cancer cells	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
105	Vesiclepedia_1273	24058411	Homo sapiens	Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
106	Vesiclepedia_1779	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
107	Vesiclepedia_3381	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
108	Vesiclepedia_2301	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Blood	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
109	Vesiclepedia_2786	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
110	Vesiclepedia_1756	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
111	Vesiclepedia_2409	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Platelets	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
112	Vesiclepedia_1479	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
113	Vesiclepedia_2953	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
114	Vesiclepedia_1965	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
115	Vesiclepedia_1175	29854963	Homo sapiens	Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.	Urine	miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
116	Vesiclepedia_3570	29971917	Rattus norvegicus	Leukocytes as a reservoir of circulating oncogenic DNA and regulatory targets of tumor-derived extracellular vesicles	Intestinal epithelial cells	dsDNA	Ultracentrifugation	Extracellular vesicles	EVs
117	Vesiclepedia_2931	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
118	Vesiclepedia_1880	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
119	Vesiclepedia_3436	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
120	Vesiclepedia_2963	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
121	Vesiclepedia_3110	30967557	Mus musculus	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a	Hippocampal neuronal cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
122	Vesiclepedia_894	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
123	Vesiclepedia_2795	37309723	Mus musculus	Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells	T-cell lymphoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
124	Vesiclepedia_2711	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Kidney cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
125	Vesiclepedia_2847	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
126	Vesiclepedia_3178	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
127	Vesiclepedia_2961	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
128	Vesiclepedia_3257	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
129	Vesiclepedia_1649	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
130	Vesiclepedia_578	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Breast cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
131	Vesiclepedia_2146	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
132	Vesiclepedia_1501	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
133	Vesiclepedia_2091	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
134	Vesiclepedia_2802	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
135	Vesiclepedia_2379	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
136	Vesiclepedia_1377	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
137	Vesiclepedia_1026	22327366	Homo sapiens	Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.	Vascular endothelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
138	Vesiclepedia_2495	34370714	Homo sapiens	MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression	Serum	mRNA	Polyethylene glycol-based precipitation Centrifugation	Extracellular vesicles	EVs
139	Vesiclepedia_2359	36708245	Homo sapiens	Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases	Blood	Protein Lipid	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
140	Vesiclepedia_1192	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
141	Vesiclepedia_2049	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
142	Vesiclepedia_1582	33785738	Homo sapiens	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Osteosarcoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
143	Vesiclepedia_1616	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
144	Vesiclepedia_1975	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
145	Vesiclepedia_1789	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
146	Vesiclepedia_871	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
147	Vesiclepedia_2545	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Large EVs
148	Vesiclepedia_3348	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Breast cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
149	Vesiclepedia_3519	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
150	Vesiclepedia_2491	34370714	Homo sapiens	MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression	Wound fluid	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
151	Vesiclepedia_2730	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
152	Vesiclepedia_2543	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
153	Vesiclepedia_1800	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Size exclusion chromatography	Extracellular vesicles	Small EVs
154	Vesiclepedia_1558	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
155	Vesiclepedia_1928	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
156	Vesiclepedia_3493	31278254	Mus musculus	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
157	Vesiclepedia_2734	35545056	Mus musculus	MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	Bone marrow cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
158	Vesiclepedia_939	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
159	Vesiclepedia_2032	36123372	Homo sapiens	Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells	Glioma stem cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
160	Vesiclepedia_1615	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
161	Vesiclepedia_2808	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
162	Vesiclepedia_1956	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
163	Vesiclepedia_2726	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
164	Vesiclepedia_3325	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
165	Vesiclepedia_1717	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
166	Vesiclepedia_1705	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
167	Vesiclepedia_2836	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
168	Vesiclepedia_2275	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
169	Vesiclepedia_1847	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
170	Vesiclepedia_2547	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
171	Vesiclepedia_588	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
172	Vesiclepedia_2432	29320704	Homo sapiens	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise	Plasma	Protein	Ultracentrifugation	Extracellular vesicles	EVs
173	Vesiclepedia_1166	29904572	Bos taurus	A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk.	Bovine milk	Protein miRNA	Differential centrifugation Density gradient centrifugation	Extracellular vesicles	EVs
174	Vesiclepedia_1372	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
175	Vesiclepedia_2785	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
176	Vesiclepedia_3314	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
177	Vesiclepedia_1223	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Exo-spin	Extracellular vesicles	EVs
178	Vesiclepedia_2942	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
179	Vesiclepedia_2009	35979935	Homo sapiens	Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients	Serum	Protein Lipid	Differential centrifugation	Extracellular vesicles	EVs
180	Vesiclepedia_2526	34315885	Mus musculus	Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease	Embryonic kidney cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
181	Vesiclepedia_2118	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
182	Vesiclepedia_2959	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
183	Vesiclepedia_1785	35927827	Mus musculus	Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles	Dendritic cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
184	Vesiclepedia_2793	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
185	Vesiclepedia_2011	36417867	Homo sapiens	Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
186	Vesiclepedia_984	25287304	Candida albicans	Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans.	Candida albicans	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
187	Vesiclepedia_2134	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Serum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
188	Vesiclepedia_1897	36260670	Mus musculus	Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice	Mesenchymal stem cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
189	Vesiclepedia_3443	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
190	Vesiclepedia_3109	30967557	Mus musculus	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a	Hippocampal neuronal cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
191	Vesiclepedia_1485	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
192	Vesiclepedia_2587	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
193	Vesiclepedia_2205	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
194	Vesiclepedia_3246	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung epithelial cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
195	Vesiclepedia_980	25471885	Drosophila melanogaster	The ESCRT machinery regulates the secretion and long-range activity of Hedgehog.	Drosophila wing imaginal Disc	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
196	Vesiclepedia_2140	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Serum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
197	Vesiclepedia_2727	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
198	Vesiclepedia_1498	33991177	Homo sapiens	Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells	Gastric cancer cells	Protein	Differential centrifugation Ultracentrifugation	Large extracellular vesicles	Large EVs
199	Vesiclepedia_611	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
200	Vesiclepedia_2043	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatocytes	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
201	Vesiclepedia_442	22288420	Paracoccidioides brasiliensis	Vesicle and vesicle-free extracellular proteome of Paracoccidioides brasiliensis: comparative analysis with other pathogenic fungi.	Paracoccidioides brasiliensis	Protein	-	Extracellular vesicles	EVs
202	Vesiclepedia_3195	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
203	Vesiclepedia_2357	36708245	Homo sapiens	Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases	Faeces	Protein Lipid	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
204	Vesiclepedia_2843	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
205	Vesiclepedia_2070	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
206	Vesiclepedia_2676	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic duct epithelial cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
207	Vesiclepedia_1521	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Embryonic kidney cells	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
208	Vesiclepedia_2947	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
209	Vesiclepedia_3550	35696959	Homo sapiens	Utility of cell-free transrenal DNA for the diagnosis of Tuberculous Meningitis: A proof-of-concept study	Urine	dsDNA	Exosome Isolation Kit	Extracellular Vesicles	EVs
210	Vesiclepedia_1607	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
211	Vesiclepedia_853	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
212	Vesiclepedia_1213	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultracentrifugation	Extracellular vesicles	EVs
213	Vesiclepedia_602	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Leukemia cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
214	Vesiclepedia_2390	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
215	Vesiclepedia_2933	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
216	Vesiclepedia_2057	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
217	Vesiclepedia_873	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
218	Vesiclepedia_1720	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
219	Vesiclepedia_1646	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Forebrain neurons	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
220	Vesiclepedia_2864	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
221	Vesiclepedia_3225	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
222	Vesiclepedia_1397	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein Lipid	Differential centrifugation Tangential flow filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
223	Vesiclepedia_1255	24468161	Homo sapiens	Molecular characterization of exosome-like vesicles from breast cancer cells.	Breast cancer cells	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
224	Vesiclepedia_2884	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Serum	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
225	Vesiclepedia_3202	34596354	Homo sapiens	Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p	Mesenchymal stem cells	Protein miRNA	Tangential flow filtration	Extracellular vesicles	Small EVs
226	Vesiclepedia_2196	29511463	Bos taurus	Biocompatibility of highly purified bovine milk-derived extracellular vesicles	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
227	Vesiclepedia_2728	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
228	Vesiclepedia_603	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Leukemia cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
229	Vesiclepedia_3525	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
230	Vesiclepedia_2408	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Adipocytes	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
231	Vesiclepedia_1583	33686255	Homo sapiens	Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy.	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
232	Vesiclepedia_845	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
233	Vesiclepedia_1384	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
234	Vesiclepedia_2819	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
235	Vesiclepedia_2829	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
236	Vesiclepedia_3317	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
237	Vesiclepedia_2958	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
238	Vesiclepedia_2517	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
239	Vesiclepedia_2780	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	Protein	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
240	Vesiclepedia_3085	35665306	Mus musculus	Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles	Serum	Protein	Size exclusion chromatography Ultracentrifugation	Extracellular vesicles	Small EVs
241	Vesiclepedia_3310	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
242	Vesiclepedia_2714	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
243	Vesiclepedia_569	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (CD9 FT)	Extracellular vesicles	EVs
244	Vesiclepedia_1890	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
245	Vesiclepedia_2416	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
246	Vesiclepedia_931	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urothelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
247	Vesiclepedia_3423	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
248	Vesiclepedia_3500	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
249	Vesiclepedia_3288	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
250	Vesiclepedia_1515	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
251	Vesiclepedia_2385	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
252	Vesiclepedia_3365	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Colon cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
253	Vesiclepedia_2141	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Serum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
254	Vesiclepedia_3484	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
255	Vesiclepedia_3207	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
256	Vesiclepedia_3433	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
257	Vesiclepedia_991	25138791	Homo sapiens	The exocyst and regulatory GTPases in urinary exosomes.	Urine	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
258	Vesiclepedia_3473	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
259	Vesiclepedia_2484	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
260	Vesiclepedia_2376	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
261	Vesiclepedia_1563	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
262	Vesiclepedia_2927	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
263	Vesiclepedia_607	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Leukemia cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
264	Vesiclepedia_3263	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Plasma	Protein	ExoQuick Kit	Small extracellular vesicles	EVs
265	Vesiclepedia_3530	30936474	Homo sapiens	Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells	Macrophage	lncRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
266	Vesiclepedia_2103	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
267	Vesiclepedia_2396	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
268	Vesiclepedia_2311	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	B cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
269	Vesiclepedia_3474	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
270	Vesiclepedia_3184	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
271	Vesiclepedia_1565	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
272	Vesiclepedia_1854	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
273	Vesiclepedia_2483	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
274	Vesiclepedia_2225	34596356	Homo sapiens	Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer	Primary prostate stromal cells	mRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
275	Vesiclepedia_2555	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
276	Vesiclepedia_1878	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
277	Vesiclepedia_3168	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
278	Vesiclepedia_1493	33991177	Homo sapiens	Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells	Gastric cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
279	Vesiclepedia_2787	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
280	Vesiclepedia_3203	34596354	Homo sapiens	Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p	Mesenchymal stem cells	Protein	Tangential flow filtration	Extracellular vesicles	Small EVs
281	Vesiclepedia_2520	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
282	Vesiclepedia_1584	33692129	Macaca fascicularis	Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	Mesenchymal stem cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
283	Vesiclepedia_624	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
284	Vesiclepedia_3220	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
285	Vesiclepedia_1370	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
286	Vesiclepedia_3425	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
287	Vesiclepedia_3248	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
288	Vesiclepedia_3322	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
289	Vesiclepedia_2706	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
290	Vesiclepedia_2960	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
291	Vesiclepedia_2329	32487994	Homo sapiens	Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence	Plasma	Protein	Centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
292	Vesiclepedia_1977	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
293	Vesiclepedia_1415	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
294	Vesiclepedia_2263	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
295	Vesiclepedia_2300	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
296	Vesiclepedia_3548	34575975	Homo sapiens	Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells	Plasma	dsDNA	Size exclusion chromatography Ultrafiltration	Extracellular Vesicles	EVs
297	Vesiclepedia_2536	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
298	Vesiclepedia_615	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
299	Vesiclepedia_1241	25329303	Homo sapiens	Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins.	Urine	Protein	Vn96 peptide precipitation	Extracellular vesicles	EVs
300	Vesiclepedia_2085	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
301	Vesiclepedia_568	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (CD9 PD)	Extracellular vesicles	EVs
302	Vesiclepedia_2832	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
303	Vesiclepedia_3094	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
304	Vesiclepedia_3518	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
305	Vesiclepedia_1239	25329303	Homo sapiens	Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins.	Urine	Protein	Vn96 peptide precipitation	Extracellular vesicles	EVs
306	Vesiclepedia_2050	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
307	Vesiclepedia_3291	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
308	Vesiclepedia_3489	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Immunoaffinity capture Centrifugation	Extracellular vesicles	Small EVs
309	Vesiclepedia_3319	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
310	Vesiclepedia_2288	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Natural killer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
311	Vesiclepedia_1798	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
312	Vesiclepedia_1844	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Colorectal cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
313	Vesiclepedia_849	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
314	Vesiclepedia_1605	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
315	Vesiclepedia_1581	33785738	Homo sapiens	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Osteosarcoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
316	Vesiclepedia_2157	34140472	Amblyomma americanum	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Amblyomma americanum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
317	Vesiclepedia_1635	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
318	Vesiclepedia_2905	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
319	Vesiclepedia_548	24009880	Homo sapiens	Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.	Mast cells	mRNA	-	Exosomes/Extracellular vesicles	EVs
320	Vesiclepedia_1752	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
321	Vesiclepedia_1240	25329303	Homo sapiens	Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins.	Urine	Protein	Ultracentrifugation	Extracellular vesicles	EVs
322	Vesiclepedia_567	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (Igg1 FT)	Extracellular vesicles	EVs
323	Vesiclepedia_855	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
324	Vesiclepedia_2013	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation	Medium extracellular vesicles	Large EVs
325	Vesiclepedia_3329	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
326	Vesiclepedia_2047	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Plasma	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
327	Vesiclepedia_2042	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatocytes	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
328	Vesiclepedia_1905	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
329	Vesiclepedia_3487	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
330	Vesiclepedia_3293	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
331	Vesiclepedia_2374	35087866	Rattus norvegicus	Exercise-Induced Extracellular Vesicles Delay the Progression of Prostate Cancer	Plasma	RNA	Size exclusion chromatography Filtration	Extracellular vesicles	Small EVs
332	Vesiclepedia_3217	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
333	Vesiclepedia_2078	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
334	Vesiclepedia_3549	31684971	Homo sapiens	Detection of fetal trisomy and single gene disease by massively parallel sequencing of extracellular vesicle DNA in maternal plasma: a proof-of-concept validation	Plasma	dsDNA	ExoQuick Kit	Extracellular Vesicles	EVs
335	Vesiclepedia_2527	34315885	Mus musculus	Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease	Kidney epithelial cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
336	Vesiclepedia_2121	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
337	Vesiclepedia_3256	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
338	Vesiclepedia_2119	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
339	Vesiclepedia_3043	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
340	Vesiclepedia_1190	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
341	Vesiclepedia_2258	37376799	Bos taurus	Bovine milk-derived extracellular vesicles enhance doxorubicin sensitivity in triple negative breast cancer cells by targeting metabolism and STAT signalling	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
342	Vesiclepedia_1618	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Large EVs
343	Vesiclepedia_2083	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
344	Vesiclepedia_1554	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
345	Vesiclepedia_2932	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
346	Vesiclepedia_2833	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
347	Vesiclepedia_1186	28326167	Homo sapiens	Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment.	Urine	Protein	Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
348	Vesiclepedia_2366	36759608	Mus musculus	Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo	Adipocytes	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
349	Vesiclepedia_1866	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
350	Vesiclepedia_2848	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
351	Vesiclepedia_1381	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
352	Vesiclepedia_2309	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Natural killer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
353	Vesiclepedia_1300	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
354	Vesiclepedia_1930	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
355	Vesiclepedia_2731	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
356	Vesiclepedia_2383	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
357	Vesiclepedia_2398	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
358	Vesiclepedia_2792	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
359	Vesiclepedia_2883	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Serum	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
360	Vesiclepedia_1227	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
361	Vesiclepedia_3307	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
362	Vesiclepedia_1058	30035390	Mus musculus	Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles.	Mouse embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
363	Vesiclepedia_2186	33792189	Mus musculus	A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions	Epididymal epithelial cells	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
364	Vesiclepedia_1386	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
365	Vesiclepedia_1576	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
366	Vesiclepedia_625	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
367	Vesiclepedia_3224	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
368	Vesiclepedia_2810	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
369	Vesiclepedia_1049	28842968	Homo sapiens	Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles.	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
370	Vesiclepedia_1422	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
371	Vesiclepedia_2113	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
372	Vesiclepedia_1176	29854963	Homo sapiens	Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.	Urine	miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
373	Vesiclepedia_1617	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Large EVs
374	Vesiclepedia_3457	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Fibroblasts	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
375	Vesiclepedia_469	23029346	Echinostoma caproni	Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells.	Echinostoma caproni	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
376	Vesiclepedia_2199	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
377	Vesiclepedia_2046	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Fibroblasts	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
378	Vesiclepedia_594	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
379	Vesiclepedia_2222	34596356	Homo sapiens	Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer	Primary prostate stromal cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
380	Vesiclepedia_2079	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
381	Vesiclepedia_1931	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
382	Vesiclepedia_3469	35393416	Homo sapiens	CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity	Oral cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
383	Vesiclepedia_2688	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein	EVtrap	Extracellular vesicles	Small EVs
384	Vesiclepedia_1486	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
385	Vesiclepedia_1763	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
386	Vesiclepedia_2677	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic duct epithelial cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
387	Vesiclepedia_2689	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein	EVtrap	Extracellular vesicles	Small EVs
388	Vesiclepedia_3096	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
389	Vesiclepedia_1963	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
390	Vesiclepedia_1429	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
391	Vesiclepedia_3538	27441821	Homo sapiens	BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal DNA is a Useful Marker For Early Detection of Gastric Cancer in an H. pylori-Independent Manner	Gastric washes	dsDNA	ExoQuick Kit	Extracellular Vesicles	EVs
392	Vesiclepedia_2206	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
393	Vesiclepedia_628	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
394	Vesiclepedia_582	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
395	Vesiclepedia_2851	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
396	Vesiclepedia_2418	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
397	Vesiclepedia_2197	33828139	Bos taurus	Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition	Bovine milk	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
398	Vesiclepedia_745	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
399	Vesiclepedia_2195	29511463	Bos taurus	Biocompatibility of highly purified bovine milk-derived extracellular vesicles	Bovine milk	Protein	Acidification Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
400	Vesiclepedia_626	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
401	Vesiclepedia_2898	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
402	Vesiclepedia_859	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
403	Vesiclepedia_3574	36289852	Homo sapiens	Next-Generation Sequencing Comparative Analysis of DNA Mutations between Blood-Derived Extracellular Vesicles and Matched Cancer Tissue in Patients with Grade 4 Glioblastoma	Plasma	dsDNA-mutated	ExoEasy Maxi Kit	Extracellular Vesicles	EVs
404	Vesiclepedia_546	23983189	Homo sapiens	Characterization of Multiple Myeloma Vesicles by Label-Free Relative Quantitation.	B cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
405	Vesiclepedia_1195	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
406	Vesiclepedia_3316	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
407	Vesiclepedia_1873	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
408	Vesiclepedia_2171	29643357	Staphylococcus aureus	Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform	Staphylococcus aureus	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
409	Vesiclepedia_1472	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
410	Vesiclepedia_3101	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
411	Vesiclepedia_1948	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
412	Vesiclepedia_750	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
413	Vesiclepedia_1904	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
414	Vesiclepedia_2799	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
415	Vesiclepedia_3190	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
416	Vesiclepedia_2723	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
417	Vesiclepedia_2936	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
418	Vesiclepedia_2330	32487994	Homo sapiens	Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence	Plasma	Protein	Centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
419	Vesiclepedia_2582	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
420	Vesiclepedia_906	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer	Urothelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
421	Vesiclepedia_1211	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
422	Vesiclepedia_3187	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
423	Vesiclepedia_3526	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
424	Vesiclepedia_1988	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
425	Vesiclepedia_866	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
426	Vesiclepedia_2082	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
427	Vesiclepedia_1362	32132711	Homo sapiens	Decoy exosomes provide protection against bacterial toxins	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Large EVs
428	Vesiclepedia_1754	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
429	Vesiclepedia_2724	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
430	Vesiclepedia_1985	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
431	Vesiclepedia_1801	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Size exclusion chromatography	Extracellular vesicles	Small EVs
432	Vesiclepedia_2384	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
433	Vesiclepedia_571	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (CD63 FT)	Extracellular vesicles	EVs
434	Vesiclepedia_1404	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
435	Vesiclepedia_604	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Leukemia cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
436	Vesiclepedia_1969	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
437	Vesiclepedia_1885	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
438	Vesiclepedia_592	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
439	Vesiclepedia_3573	36125881	Mus musculus	Cell-free DNA topology depends on its subcellular and cellular origins in cancer	Plasma	mtDNA	Differential centrifugation	Extracellular Vesicles	EVs
440	Vesiclepedia_1645	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Forebrain neurons	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
441	Vesiclepedia_597	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
442	Vesiclepedia_3264	34654817	Mus musculus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Microglia	miRNA	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
443	Vesiclepedia_3504	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
444	Vesiclepedia_1037	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	miRCURY Exosome Isolation Kit	Extracellular vesicles	EVs
445	Vesiclepedia_955	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
446	Vesiclepedia_3442	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
447	Vesiclepedia_1797	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
448	Vesiclepedia_3176	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
449	Vesiclepedia_3037	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
450	Vesiclepedia_2087	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
451	Vesiclepedia_631	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
452	Vesiclepedia_1857	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
453	Vesiclepedia_1594	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
454	Vesiclepedia_3373	33510128	Mus musculus	Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia	Colon cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
455	Vesiclepedia_2448	34465793	Homo sapiens	Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer	Breast cancer cells	miRNA	Centrifugation Ultracentrifugation	Extracellular vesicles	EVs
456	Vesiclepedia_2715	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
457	Vesiclepedia_1596	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
458	Vesiclepedia_3583	33375577	Homo sapiens	Comparison of Circulating Tumour DNA and Extracellular Vesicle DNA by Low-Pass Whole-Genome Sequencing Reveals Molecular Drivers of Disease in a Breast Cancer Patient	Plasma	dsDNA-mutated	Differential centrifugation Ultracentrifugation	Extracellular Vesicles	EVs
459	Vesiclepedia_632	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
460	Vesiclepedia_2580	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
461	Vesiclepedia_2435	29320704	Homo sapiens	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise	Plasma	Protein	Centrifugation	Extracellular vesicles	EVs
462	Vesiclepedia_920	28687758	Sus scrofa	Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers	Polarised retinal pigmented epithelial cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
463	Vesiclepedia_2720	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
464	Vesiclepedia_1972	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
465	Vesiclepedia_1389	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
466	Vesiclepedia_2516	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Large EVs
467	Vesiclepedia_3422	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
468	Vesiclepedia_1491	32024826	Homo sapiens	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Plasma	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
469	Vesiclepedia_1376	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
470	Vesiclepedia_3496	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
471	Vesiclepedia_872	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
472	Vesiclepedia_3087	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
473	Vesiclepedia_2401	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
474	Vesiclepedia_1938	36193887	Homo sapiens	Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
475	Vesiclepedia_3453	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
476	Vesiclepedia_3287	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
477	Vesiclepedia_2107	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
478	Vesiclepedia_909	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer	Transitional carcinoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
479	Vesiclepedia_3523	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
480	Vesiclepedia_2881	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Serum	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
481	Vesiclepedia_2080	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
482	Vesiclepedia_1629	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
483	Vesiclepedia_417	20956325	Bacillus anthracis	Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins.	Bacillus anthracis	Lipids	-	Extracellular vesicles	EVs
484	Vesiclepedia_484	23214914	Trypanosoma cruzi	Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.	Epimastigotes	Protein	-	Exosomes/Extracellular vesicles/Ectosomes	EVs
485	Vesiclepedia_627	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
486	Vesiclepedia_1050	28842968	Homo sapiens	Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles.	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
487	Vesiclepedia_1783	35932288	Homo sapiens	Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
488	Vesiclepedia_1402	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
489	Vesiclepedia_2885	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
490	Vesiclepedia_616	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
491	Vesiclepedia_1919	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Lung cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
492	Vesiclepedia_3430	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
493	Vesiclepedia_3098	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
494	Vesiclepedia_2783	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
495	Vesiclepedia_1505	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
496	Vesiclepedia_3463	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
497	Vesiclepedia_3180	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
498	Vesiclepedia_486	23230278	Homo sapiens	Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids.	Colorectal cancer cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
499	Vesiclepedia_1171	29881354	Rattus norvegicus	Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content.	Serum	Protein miRNA	ExoQuick	Extracellular vesicles	EVs
500	Vesiclepedia_1863	35931686	Homo sapiens	Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression	Chondrocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
501	Vesiclepedia_2860	33579909	Mus musculus	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
502	Vesiclepedia_1183	28684402	Homo sapiens	BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells	Melanoma cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	EVs
503	Vesiclepedia_2535	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
504	Vesiclepedia_2561	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
505	Vesiclepedia_3387	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	-	Extracellular vesicles	Small EVs
506	Vesiclepedia_2609	32383290	Ovis aries	Quantitative Proteomic Analysis of Seminal Plasma, Sperm Membrane Proteins, and Seminal Extracellular Vesicles Suggests Vesicular Mechanisms Aid in the Removal and Addition of Proteins to the Ram Sperm Membrane	Seminal plasma	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
507	Vesiclepedia_2790	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Liver	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
508	Vesiclepedia_3449	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
509	Vesiclepedia_1509	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
510	Vesiclepedia_2928	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
511	Vesiclepedia_2211	37043568	Bos taurus	Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis	Bovine milk	Protein	Differential centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
512	Vesiclepedia_1238	25329303	Homo sapiens	Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins.	Urine	Protein	Ultracentrifugation	Extracellular vesicles	EVs
513	Vesiclepedia_1923	36214496	Mus musculus	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Motor neuron-like cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
514	Vesiclepedia_2704	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
515	Vesiclepedia_2591	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
516	Vesiclepedia_1894	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
517	Vesiclepedia_3424	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
518	Vesiclepedia_2056	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
519	Vesiclepedia_3312	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
520	Vesiclepedia_3512	31068461	Homo sapiens	Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
521	Vesiclepedia_623	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
522	Vesiclepedia_2417	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
523	Vesiclepedia_956	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
524	Vesiclepedia_3092	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
525	Vesiclepedia_3265	34654817	Mus musculus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Microglia	miRNA	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
526	Vesiclepedia_1726	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
527	Vesiclepedia_2556	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
528	Vesiclepedia_1392	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein	Differential centrifugation Tangential flow filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
529	Vesiclepedia_1210	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
530	Vesiclepedia_942	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
531	Vesiclepedia_2805	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
532	Vesiclepedia_3462	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
533	Vesiclepedia_1887	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
534	Vesiclepedia_1314	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
535	Vesiclepedia_2563	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
536	Vesiclepedia_1024	22327366	Homo sapiens	Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.	Vascular endothelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
537	Vesiclepedia_3182	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
538	Vesiclepedia_1065	29963299	Homo sapiens	Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography.	Synovial fluid	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
539	Vesiclepedia_3501	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
540	Vesiclepedia_2511	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
541	Vesiclepedia_1511	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
542	Vesiclepedia_1313	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
543	Vesiclepedia_2044	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
544	Vesiclepedia_2290	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Acute lymphoblastic leukemia cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
545	Vesiclepedia_857	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
546	Vesiclepedia_1852	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
547	Vesiclepedia_1474	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
548	Vesiclepedia_1265	24310399	Homo sapiens	Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1.	Glioblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	EVs
549	Vesiclepedia_1886	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
550	Vesiclepedia_2094	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
551	Vesiclepedia_2550	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
552	Vesiclepedia_3214	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanocytes	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
553	Vesiclepedia_2736	35545056	Mus musculus	MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	Bone marrow cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
554	Vesiclepedia_1966	35915084	Mus musculus	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
555	Vesiclepedia_3454	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
556	Vesiclepedia_3492	31278254	Mus musculus	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
557	Vesiclepedia_596	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
558	Vesiclepedia_414	20559436	Saccharomyces cerevisiae	Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis.	Saccharomyces cerevisiae	Protein	-	Extracellular vesicles	EVs
559	Vesiclepedia_650	29188495	Homo sapiens	Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.	Cerebrospinal fluid	Protein	Differential centrifugation Ultracentrifugation Sonication Filtration	Extracellular vesicles	EVs
560	Vesiclepedia_2143	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
561	Vesiclepedia_3465	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
562	Vesiclepedia_2863	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
563	Vesiclepedia_2126	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
564	Vesiclepedia_1796	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
565	Vesiclepedia_243	22149170	Homo sapiens	The Protein Interaction Network of Extracellular Vesicles Derived from Human Colorectal Cancer Cells	Colorectal cancer cells	Protein	Differential centrifugation Ultrafiltration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
566	Vesiclepedia_2934	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
567	Vesiclepedia_2904	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
568	Vesiclepedia_2532	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
569	Vesiclepedia_1855	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
570	Vesiclepedia_3105	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
571	Vesiclepedia_1744	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
572	Vesiclepedia_586	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
573	Vesiclepedia_1755	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
574	Vesiclepedia_3467	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
575	Vesiclepedia_2226	34596356	Homo sapiens	Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer	Primary prostate stromal cells	mRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
576	Vesiclepedia_630	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
577	Vesiclepedia_2269	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
578	Vesiclepedia_2814	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
579	Vesiclepedia_581	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
580	Vesiclepedia_1633	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
581	Vesiclepedia_2854	33579909	Homo sapiens	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
582	Vesiclepedia_2525	34315885	Mus musculus	Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease	Embryonic kidney cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
583	Vesiclepedia_2100	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
584	Vesiclepedia_1383	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
585	Vesiclepedia_2494	34370714	Homo sapiens	MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression	Serum	mRNA	Polyethylene glycol-based precipitation Centrifugation	Extracellular vesicles	EVs
586	Vesiclepedia_3327	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
587	Vesiclepedia_908	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer	Transitional carcinoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
588	Vesiclepedia_856	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
589	Vesiclepedia_2939	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
590	Vesiclepedia_952	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
591	Vesiclepedia_1194	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
592	Vesiclepedia_1033	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
593	Vesiclepedia_549	24009881	Homo sapiens	Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells.	Colorectal cancer cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles/Ectosomes	EVs
594	Vesiclepedia_3503	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
595	Vesiclepedia_3321	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
596	Vesiclepedia_2317	31762962	Homo sapiens	Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers	Plasma	Protein small RNA	ExoQuick Kit	Extracellular vesicles/Exosomes	EVs
597	Vesiclepedia_2132	36515353	Homo sapiens	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	Plasma	Metabolite Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
598	Vesiclepedia_3041	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
599	Vesiclepedia_2572	35689797	Homo sapiens	Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations	Mammary epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
600	Vesiclepedia_1380	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
601	Vesiclepedia_2876	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
602	Vesiclepedia_2019	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation	Medium extracellular vesicles	Large EVs
603	Vesiclepedia_2291	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Glioma cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
604	Vesiclepedia_2880	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Melanoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
605	Vesiclepedia_3529	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
606	Vesiclepedia_1564	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
607	Vesiclepedia_3427	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
608	Vesiclepedia_1651	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
609	Vesiclepedia_3546	36149031	Homo sapiens	Extracellular vesicle-bound DNA in urine is indicative of kidney allograft injury	Urine	dsDNA	Size exclusion chromatography	Extracellular Vesicles	EVs
610	Vesiclepedia_576	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Breast cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
611	Vesiclepedia_1711	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
612	Vesiclepedia_1599	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
613	Vesiclepedia_934	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Bladder cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
614	Vesiclepedia_2583	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
615	Vesiclepedia_2797	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
616	Vesiclepedia_3179	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
617	Vesiclepedia_2410	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Hepatocytes	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
618	Vesiclepedia_2861	33579909	Mus musculus	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
619	Vesiclepedia_1177	29854963	Homo sapiens	Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.	Urine	miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
620	Vesiclepedia_1620	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
621	Vesiclepedia_2128	36515353	Homo sapiens	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	Plasma	Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
622	Vesiclepedia_2393	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
623	Vesiclepedia_1891	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
624	Vesiclepedia_2411	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Leukocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
625	Vesiclepedia_1405	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
626	Vesiclepedia_3515	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
627	Vesiclepedia_2887	30918259	Mus musculus	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
628	Vesiclepedia_1946	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
629	Vesiclepedia_1039	27770278	Homo sapiens	Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.	Glioblastoma cells	Protein	Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation	Extracellular vesicles	EVs
630	Vesiclepedia_2571	35689797	Homo sapiens	Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations	Mammary epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
631	Vesiclepedia_591	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
632	Vesiclepedia_1918	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Epidermoid cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
633	Vesiclepedia_3318	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
634	Vesiclepedia_2593	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung epithelial cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
635	Vesiclepedia_1644	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
636	Vesiclepedia_1976	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
637	Vesiclepedia_3167	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
638	Vesiclepedia_2530	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
639	Vesiclepedia_2059	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
640	Vesiclepedia_2503	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	exoEasy Maxi Kit	Extracellular vesicles	EVs
641	Vesiclepedia_932	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Bladder cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
642	Vesiclepedia_2538	34293122	Mus musculus	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein Lipid	Centrifugation	Extracellular vesicles	Large EVs
643	Vesiclepedia_1883	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
644	Vesiclepedia_502	23436686	Homo sapiens	A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.	Endothelial cells	Protein	-	Membrane vesicles/Extracellular vesicles	EVs
645	Vesiclepedia_1182	28684402	Homo sapiens	BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells	Melanoma cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	EVs
646	Vesiclepedia_1941	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
647	Vesiclepedia_2482	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
648	Vesiclepedia_3255	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
649	Vesiclepedia_3324	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
650	Vesiclepedia_3452	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
651	Vesiclepedia_1393	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein	Differential centrifugation Tangential flow filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
652	Vesiclepedia_3108	30967557	Mus musculus	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a	Hippocampal neuronal cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
653	Vesiclepedia_1309	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
654	Vesiclepedia_2788	35304471	Homo sapiens	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
655	Vesiclepedia_2850	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
656	Vesiclepedia_1730	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
657	Vesiclepedia_2048	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Plasma	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
658	Vesiclepedia_1042	27770278	Homo sapiens	Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.	Glioblastoma cells	Protein	Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation	Extracellular vesicles	EVs
659	Vesiclepedia_2924	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
660	Vesiclepedia_1165	29904572	Bos taurus	A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk.	Bovine milk	Protein miRNA	Differential centrifugation Density gradient centrifugation	Extracellular vesicles	EVs
661	Vesiclepedia_3165	34772807	Clonorchis sinensis	Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries	Clonorchis sinensis	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
662	Vesiclepedia_1909	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
663	Vesiclepedia_2712	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Kidney cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
664	Vesiclepedia_1423	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
665	Vesiclepedia_1986	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
666	Vesiclepedia_889	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
667	Vesiclepedia_2778	35304471	Homo sapiens	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	Protein	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
668	Vesiclepedia_605	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Leukemia cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
669	Vesiclepedia_3227	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
670	Vesiclepedia_2794	37309723	Mus musculus	Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells	Colon cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
671	Vesiclepedia_2796	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
672	Vesiclepedia_1971	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
673	Vesiclepedia_2877	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Melanoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
674	Vesiclepedia_2859	33579909	Mus musculus	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
675	Vesiclepedia_3268	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Plasma	Protein	ExoQuick Kit	Small extracellular vesicles	EVs
676	Vesiclepedia_3417	33391636	Homo sapiens	Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus	Embryonic kidney cells	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
677	Vesiclepedia_2224	34596356	Homo sapiens	Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer	Primary prostate stromal cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
678	Vesiclepedia_2492	34370714	Homo sapiens	MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression	Wound fluid	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
679	Vesiclepedia_2364	36748335	Homo sapiens	Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α	Oral cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
680	Vesiclepedia_1648	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
681	Vesiclepedia_1575	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
682	Vesiclepedia_1729	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
683	Vesiclepedia_893	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
684	Vesiclepedia_2392	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
685	Vesiclepedia_2853	33579909	Homo sapiens	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
686	Vesiclepedia_1361	32132711	Homo sapiens	Decoy exosomes provide protection against bacterial toxins	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Large EVs
687	Vesiclepedia_3567	28750687	Homo sapiens	Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency	Liver stem cells	dsDNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles|Exosomes	EVs
688	Vesiclepedia_2595	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
689	Vesiclepedia_3485	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
690	Vesiclepedia_1877	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
691	Vesiclepedia_2223	34596356	Homo sapiens	Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer	Primary prostate stromal cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
692	Vesiclepedia_2033	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
693	Vesiclepedia_3566	36555692	Homo sapiens	Intravesicular Genomic DNA Enriched by Size Exclusion Chromatography Can Enhance Lung Cancer Oncogene Mutation Detection Sensitivity	Lung cancer cells	DNA	Sucrose density gradient Ultracentrifugation size exclusion chromatography	Extracellular vesicles	EVs
694	Vesiclepedia_1473	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
695	Vesiclepedia_1987	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
696	Vesiclepedia_1787	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Primary cortical neurons	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
697	Vesiclepedia_2270	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
698	Vesiclepedia_1757	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
699	Vesiclepedia_1900	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
700	Vesiclepedia_1737	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
701	Vesiclepedia_3243	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
702	Vesiclepedia_1492	32024826	Homo sapiens	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Plasma	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
703	Vesiclepedia_840	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
704	Vesiclepedia_462	22849433	Homo sapiens	Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types.	Embryonic kidney cells	miRNA	-	Extracellular vesicles	EVs
705	Vesiclepedia_3458	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Primary cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
706	Vesiclepedia_3170	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
707	Vesiclepedia_1625	34012515	Homo sapiens	CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells	Melanoma cells	Protein	Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
708	Vesiclepedia_1780	35932288	Homo sapiens	Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
709	Vesiclepedia_2839	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
710	Vesiclepedia_2088	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
711	Vesiclepedia_2831	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
712	Vesiclepedia_1029	26378940	Homo sapiens	Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
713	Vesiclepedia_945	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
714	Vesiclepedia_1634	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
715	Vesiclepedia_3211	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
716	Vesiclepedia_3295	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
717	Vesiclepedia_2272	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
718	Vesiclepedia_3338	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Colorectal cancer cells	Protein miRNA	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
719	Vesiclepedia_2170	29643357	Staphylococcus aureus	Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform	Staphylococcus aureus	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
720	Vesiclepedia_3099	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
721	Vesiclepedia_2485	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
722	Vesiclepedia_3542	33692304	Homo sapiens	Use of Liquid Biopsy to Detect PIK3CA Mutation in Metastatic Breast Cancer	Plasma	dsDNA	Exosome Isolation Kit	Extracellular Vesicles	EVs
723	Vesiclepedia_3174	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
724	Vesiclepedia_3266	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Hippocampal neuronal cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
725	Vesiclepedia_2534	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
726	Vesiclepedia_2531	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
727	Vesiclepedia_2356	36708245	Homo sapiens	Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases	Faeces	Protein Lipid	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
728	Vesiclepedia_2292	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Breast cancer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
729	Vesiclepedia_3044	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
730	Vesiclepedia_2076	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
731	Vesiclepedia_751	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
732	Vesiclepedia_2161	34140472	Ixodes scapularis	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Ixodes scapularis	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
733	Vesiclepedia_1043	27770278	Homo sapiens	Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.	Glioblastoma cells	Protein	Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation	Extracellular vesicles	EVs
734	Vesiclepedia_2513	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	exoEasy Maxi Kit	Extracellular vesicles	EVs
735	Vesiclepedia_3172	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
736	Vesiclepedia_1207	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
737	Vesiclepedia_579	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Breast cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
738	Vesiclepedia_3210	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
739	Vesiclepedia_2679	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
740	Vesiclepedia_574	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
741	Vesiclepedia_1638	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
742	Vesiclepedia_2062	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
743	Vesiclepedia_2362	36748335	Homo sapiens	Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α	Oral cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
744	Vesiclepedia_2261	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
745	Vesiclepedia_2804	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
746	Vesiclepedia_2925	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
747	Vesiclepedia_3201	36754903	Mus musculus	An extracellular vesicular mutant KRAS-associated protein complex promotes lung inflammation and tumor growth	Lung epithelial cells	Protein	Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
748	Vesiclepedia_3223	32111843	Homo sapiens	A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA	Breast cancer cells	Protein	Differential centrifugation Tangential flow filtration Filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
749	Vesiclepedia_2267	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
750	Vesiclepedia_1614	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
751	Vesiclepedia_1416	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
752	Vesiclepedia_3585	36591510	Homo sapiens	Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer	Plasma	dsDNA-mutated	Differential centrifugation Ultracentrifugation	Extracellular Vesicles	EVs
753	Vesiclepedia_3488	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
754	Vesiclepedia_3104	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
755	Vesiclepedia_3230	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
756	Vesiclepedia_598	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
757	Vesiclepedia_1502	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
758	Vesiclepedia_566	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (Igg1 PD)	Extracellular vesicles	EVs
759	Vesiclepedia_2022	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation	Medium extracellular vesicles	Large EVs
760	Vesiclepedia_1382	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
761	Vesiclepedia_3290	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
762	Vesiclepedia_2929	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
763	Vesiclepedia_2553	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
764	Vesiclepedia_3491	31278254	Mus musculus	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
765	Vesiclepedia_3213	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
766	Vesiclepedia_1932	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
767	Vesiclepedia_1710	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
768	Vesiclepedia_2122	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
769	Vesiclepedia_1850	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
770	Vesiclepedia_3335	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Colorectal cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
771	Vesiclepedia_1902	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
772	Vesiclepedia_1920	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Glioma cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
773	Vesiclepedia_1187	28326167	Homo sapiens	Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment.	Urine	Protein	Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
774	Vesiclepedia_2414	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
775	Vesiclepedia_3386	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Mammary epithelial cells	Metabolite	-	Extracellular vesicles	Small EVs
776	Vesiclepedia_1189	28326167	Homo sapiens	Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment.	Urine	Protein	Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
777	Vesiclepedia_1193	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
778	Vesiclepedia_1613	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
779	Vesiclepedia_2578	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
780	Vesiclepedia_1035	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	Exo-spin	Extracellular vesicles	EVs
781	Vesiclepedia_2738	35545056	Homo sapiens	MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
782	Vesiclepedia_2700	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
783	Vesiclepedia_3254	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
784	Vesiclepedia_1504	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
785	Vesiclepedia_2701	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
786	Vesiclepedia_3559	25086355	Rattus norvegicus	Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells	Epithelial cells	dsDNA	Filtration Ultracentrifugation	Extracellular vesicles	EVs
787	Vesiclepedia_2377	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
788	Vesiclepedia_2830	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
789	Vesiclepedia_1950	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
790	Vesiclepedia_3191	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
791	Vesiclepedia_2522	34315885	Mus musculus	Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease	Kidney epithelial cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
792	Vesiclepedia_1746	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
793	Vesiclepedia_3370	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Colon cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
794	Vesiclepedia_2055	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
795	Vesiclepedia_2116	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
796	Vesiclepedia_2045	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
797	Vesiclepedia_2502	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	ExoQuick Kit	Extracellular vesicles	EVs
798	Vesiclepedia_3520	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
799	Vesiclepedia_2540	34293122	Mus musculus	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein Lipid	Centrifugation	Extracellular vesicles	Large EVs
800	Vesiclepedia_2784	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
801	Vesiclepedia_960	26047123	Bos taurus	Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models.	Bovine milk	Protein	Differential centrifugation Ultracentrifugation Filtration	Extracellular vesicles	EVs
802	Vesiclepedia_2533	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
803	Vesiclepedia_2537	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
804	Vesiclepedia_2944	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
805	Vesiclepedia_2138	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Serum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
806	Vesiclepedia_2935	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
807	Vesiclepedia_1974	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
808	Vesiclepedia_2781	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	Protein	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
809	Vesiclepedia_1884	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
810	Vesiclepedia_1743	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
811	Vesiclepedia_3554	33375577	Homo sapiens	Comparison of Circulating Tumour DNA and Extracellular Vesicle DNA by Low-Pass Whole-Genome Sequencing Reveals Molecular Drivers of Disease in a Breast Cancer Patient	Plasma	dsDNA	Ultracentrifugation	Extracellular Vesicles	EVs
812	Vesiclepedia_3440	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
813	Vesiclepedia_606	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Leukemia cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
814	Vesiclepedia_2873	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
815	Vesiclepedia_2381	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
816	Vesiclepedia_1861	35931686	Homo sapiens	Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression	Chondrocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
817	Vesiclepedia_2865	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Melanoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
818	Vesiclepedia_2857	33579909	Mus musculus	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
819	Vesiclepedia_2015	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Centrifugation	Large extracellular vesicles	Large EVs
820	Vesiclepedia_997	24392111	Mus musculus	Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?	Murine myotubues	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
821	Vesiclepedia_1480	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
822	Vesiclepedia_3258	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
823	Vesiclepedia_3415	33391636	Homo sapiens	Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus	Colorectal cancer cells	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
824	Vesiclepedia_3494	31278254	Mus musculus	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
825	Vesiclepedia_3332	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Lung cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
826	Vesiclepedia_3088	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
827	Vesiclepedia_3516	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
828	Vesiclepedia_2187	33792189	Mus musculus	A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions	Epididymal epithelial cells	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
829	Vesiclepedia_851	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
830	Vesiclepedia_3531	30936474	Homo sapiens	Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells	Macrophage	Protein lncRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
831	Vesiclepedia_868	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
832	Vesiclepedia_1804	35917363	Homo sapiens	CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
833	Vesiclepedia_2026	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Osteosarcoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
834	Vesiclepedia_1640	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
835	Vesiclepedia_951	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
836	Vesiclepedia_3204	34596354	Homo sapiens	Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p	Mesenchymal stem cells	Protein	Tangential flow filtration	Extracellular vesicles	Small EVs
837	Vesiclepedia_2539	34293122	Mus musculus	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein	Centrifugation	Extracellular vesicles	Large EVs
838	Vesiclepedia_858	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
839	Vesiclepedia_2827	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
840	Vesiclepedia_3304	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
841	Vesiclepedia_634	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Prostate cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
842	Vesiclepedia_1419	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
843	Vesiclepedia_3323	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
844	Vesiclepedia_3330	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
845	Vesiclepedia_1179	29854963	Homo sapiens	Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.	Urine	miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
846	Vesiclepedia_944	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
847	Vesiclepedia_2370	36759608	Homo sapiens	Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo	Adipocytes	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
848	Vesiclepedia_2569	35260554	Homo sapiens	Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis	Gastric cancer cells	Protein	Centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
849	Vesiclepedia_2061	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
850	Vesiclepedia_3475	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Cystic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
851	Vesiclepedia_1776	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
852	Vesiclepedia_2690	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein	EVtrap	Extracellular vesicles	Small EVs
853	Vesiclepedia_1848	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
854	Vesiclepedia_3308	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
855	Vesiclepedia_3216	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
856	Vesiclepedia_2135	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Serum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
857	Vesiclepedia_2507	34322206	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	MagCapture Exosome Isolation Kit PS	Extracellular vesicles	EVs
858	Vesiclepedia_2955	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
859	Vesiclepedia_946	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
860	Vesiclepedia_2227	32494663	Homo sapiens	miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1	Pancreatic cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
861	Vesiclepedia_1561	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
862	Vesiclepedia_890	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
863	Vesiclepedia_1708	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
864	Vesiclepedia_3241	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
865	Vesiclepedia_1055	30035390	Mus musculus	Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles.	Mouse embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
866	Vesiclepedia_3551	34158841	Homo sapiens	Plasma-derived DNA containing-extracellular vesicles induce STING-mediated proinflammatory responses in dermatomyositis	Plasma	dsDNA	Differential centrifugation Ultracentrifugation Exosome Isolation Kit	Extracellular Vesicles	EVs
867	Vesiclepedia_1408	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
868	Vesiclepedia_1732	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
869	Vesiclepedia_1066	29963299	Homo sapiens	Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography.	Synovial fluid	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
870	Vesiclepedia_595	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
871	Vesiclepedia_622	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
872	Vesiclepedia_2519	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
873	Vesiclepedia_1782	35932288	Homo sapiens	Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
874	Vesiclepedia_613	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
875	Vesiclepedia_1639	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
876	Vesiclepedia_2200	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
877	Vesiclepedia_3547	34453041	Homo sapiens	Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway	Plasma	dsDNA	Size exclusion chromatography	Extracellular Vesicles	EVs
878	Vesiclepedia_1716	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
879	Vesiclepedia_1722	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
880	Vesiclepedia_3565	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Embroyonic fibroblasts	mtDNA	Ultracentrifugation	Extracellular vesicles	EVs
881	Vesiclepedia_2391	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
882	Vesiclepedia_2476	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
883	Vesiclepedia_1773	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
884	Vesiclepedia_2549	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
885	Vesiclepedia_1994	34188787	Mus musculus	Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation	Epididymal epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
886	Vesiclepedia_1799	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Size exclusion chromatography	Extracellular vesicles	Small EVs
887	Vesiclepedia_2021	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Centrifugation	Large extracellular vesicles	Large EVs
888	Vesiclepedia_1843	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Normal colon fibroblasts	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
889	Vesiclepedia_1781	35932288	Homo sapiens	Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
890	Vesiclepedia_1303	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
891	Vesiclepedia_1714	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
892	Vesiclepedia_1172	29881354	Rattus norvegicus	Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content.	Serum	Protein miRNA	ExoQuick	Extracellular vesicles	EVs
893	Vesiclepedia_2008	35979935	Homo sapiens	Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients	Serum	Protein Lipid	Differential centrifugation	Extracellular vesicles	EVs
894	Vesiclepedia_510	23521563	Homo sapiens	First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.	Ewing's sarcoma cells	mRNA	-	Exosomes/Extracellular vesicles	EVs
895	Vesiclepedia_1795	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
896	Vesiclepedia_2678	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
897	Vesiclepedia_1385	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
898	Vesiclepedia_587	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
899	Vesiclepedia_1791	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
900	Vesiclepedia_1631	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
901	Vesiclepedia_3435	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
902	Vesiclepedia_1023	22327366	Homo sapiens	Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.	Vascular endothelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
903	Vesiclepedia_2073	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
904	Vesiclepedia_1056	30035390	Mus musculus	Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles.	Mouse embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
905	Vesiclepedia_1725	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
906	Vesiclepedia_3569	25133686	Homo sapiens	Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice	Myelogenous leukemia cells	Genomic DNA	Ultracentrifugation	Extracellular vesicles	EVs
907	Vesiclepedia_1704	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
908	Vesiclepedia_3576	33915956	Homo sapiens	Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells	Plasma	dsDNA-mutated	Exo-RNeasy Kit	Extracellular Vesicles	EVs
909	Vesiclepedia_2318	31762962	Homo sapiens	Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers	Plasma	Protein small RNA	ExoQuick Kit	Extracellular vesicles/Exosomes	EVs
910	Vesiclepedia_1600	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
911	Vesiclepedia_1312	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
912	Vesiclepedia_2562	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
913	Vesiclepedia_2312	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	B cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
914	Vesiclepedia_1993	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
915	Vesiclepedia_633	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Prostate cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
916	Vesiclepedia_2579	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
917	Vesiclepedia_3166	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
918	Vesiclepedia_1478	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
919	Vesiclepedia_2590	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
920	Vesiclepedia_2740	35513391	Homo sapiens	Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1	Posterior longitudinal ligament	miRNA	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
921	Vesiclepedia_1735	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
922	Vesiclepedia_2557	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
923	Vesiclepedia_2874	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
924	Vesiclepedia_1030	26378940	Homo sapiens	Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
925	Vesiclepedia_839	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
926	Vesiclepedia_2159	34140472	Dermacentor andersoni	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Dermacentor andersoni	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
927	Vesiclepedia_3171	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
928	Vesiclepedia_1128	23954818	Homo sapiens	Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.	Squamous carcinoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
929	Vesiclepedia_2031	36123372	Homo sapiens	Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells	Umbilical vein endothelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
930	Vesiclepedia_1995	34188787	Mus musculus	Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation	Epididymal epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
931	Vesiclepedia_3093	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
932	Vesiclepedia_2589	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
933	Vesiclepedia_3558	28966872	Homo sapiens	Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes	Breast cancer cells	dsDNA	Differential centrifugation Filtration Ultracentrifugation	Nanoscale extracellular vesicles	EVs
934	Vesiclepedia_2271	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
935	Vesiclepedia_3089	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
936	Vesiclepedia_601	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
937	Vesiclepedia_3219	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
938	Vesiclepedia_619	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
939	Vesiclepedia_617	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
940	Vesiclepedia_2266	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
941	Vesiclepedia_1767	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
942	Vesiclepedia_2164	34140472	Ixodes scapularis	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Ixodes scapularis	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
943	Vesiclepedia_842	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
944	Vesiclepedia_509	23521563	Homo sapiens	First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.	Ewing's sarcoma cells	mRNA	-	Exosomes/Extracellular vesicles	EVs
945	Vesiclepedia_2412	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
946	Vesiclepedia_2541	34293122	Mus musculus	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein Lipid	Centrifugation	Extracellular vesicles	Large EVs
947	Vesiclepedia_1406	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
948	Vesiclepedia_2274	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
949	Vesiclepedia_1225	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Exo-spin	Extracellular vesicles	EVs
950	Vesiclepedia_3544	31232418	Homo sapiens	Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica	Plasma	dsDNA	Lipid nanoprobe functionalized nanostructured silica platform	Nanoscale extracellular Vesicles	EVs
951	Vesiclepedia_1853	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
952	Vesiclepedia_1562	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
953	Vesiclepedia_1608	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
954	Vesiclepedia_2302	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
955	Vesiclepedia_1036	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	Exo-spin	Extracellular vesicles	EVs
956	Vesiclepedia_3267	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Hippocampal neuronal cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
957	Vesiclepedia_2608	32383290	Ovis aries	Quantitative Proteomic Analysis of Seminal Plasma, Sperm Membrane Proteins, and Seminal Extracellular Vesicles Suggests Vesicular Mechanisms Aid in the Removal and Addition of Proteins to the Ram Sperm Membrane	Seminal plasma	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
958	Vesiclepedia_2512	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	ExoQuick Kit	Extracellular vesicles	EVs
959	Vesiclepedia_2477	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
960	Vesiclepedia_2397	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
961	Vesiclepedia_1208	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
962	Vesiclepedia_841	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
963	Vesiclepedia_1520	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Mast cells	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
964	Vesiclepedia_2938	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
965	Vesiclepedia_2481	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
966	Vesiclepedia_2801	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
967	Vesiclepedia_3539	33915956	Homo sapiens	Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells	Plasma	dsDNA	Exo-RNeasy Kit	Extracellular Vesicles	EVs
968	Vesiclepedia_1374	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
969	Vesiclepedia_2866	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
970	Vesiclepedia_3447	32341770	Mus musculus	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Plasma	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
971	Vesiclepedia_2729	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
972	Vesiclepedia_1721	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
973	Vesiclepedia_1060	30006486	Homo sapiens	The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells.	Astrocytoma cells	Protein	Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
974	Vesiclepedia_2858	33579909	Mus musculus	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
975	Vesiclepedia_3556	36591510	Homo sapiens	Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer	Plasma	dsDNA	Differential centrifugation Ultracentrifugation	Extracellular Vesicles	EVs
976	Vesiclepedia_1038	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	miRCURY Exosome Isolation Kit	Extracellular vesicles	EVs
977	Vesiclepedia_2405	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
978	Vesiclepedia_3244	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
979	Vesiclepedia_2051	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
980	Vesiclepedia_1771	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
981	Vesiclepedia_2900	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Gastric cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
982	Vesiclepedia_2895	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
983	Vesiclepedia_2890	28928431	Mus musculus	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90	Lung cancer cells	Protein	Centrifugal ultrafiltration ExoQuick Kit	Extracellular vesicles	EVs
984	Vesiclepedia_930	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Bladder cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
985	Vesiclepedia_1586	33692129	Macaca fascicularis	Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	Mesenchymal stem cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
986	Vesiclepedia_1471	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
987	Vesiclepedia_2010	36417867	Homo sapiens	Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
988	Vesiclepedia_1984	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
989	Vesiclepedia_3498	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
990	Vesiclepedia_2102	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
991	Vesiclepedia_2737	35545056	Homo sapiens	MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
992	Vesiclepedia_2828	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
993	Vesiclepedia_2137	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
994	Vesiclepedia_3527	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
995	Vesiclepedia_1775	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
996	Vesiclepedia_1574	33785738	Homo sapiens	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Osteosarcoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
997	Vesiclepedia_3194	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
998	Vesiclepedia_2907	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
999	Vesiclepedia_1983	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1000	Vesiclepedia_1414	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1001	Vesiclepedia_1306	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1002	Vesiclepedia_1802	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Size exclusion chromatography	Extracellular vesicles	Small EVs
1003	Vesiclepedia_748	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
1004	Vesiclepedia_2145	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1005	Vesiclepedia_2142	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Serum	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1006	Vesiclepedia_483	23214914	Trypanosoma cruzi	Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.	Epimastigotes	Protein	-	Exosomes/Extracellular vesicles/Ectosomes	EVs
1007	Vesiclepedia_2160	34140472	Ixodes scapularis	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Salivary glands	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1008	Vesiclepedia_1588	33692129	Macaca fascicularis	Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	Mesenchymal stem cells	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1009	Vesiclepedia_2838	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1010	Vesiclepedia_1751	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1011	Vesiclepedia_2072	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1012	Vesiclepedia_2096	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1013	Vesiclepedia_614	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1014	Vesiclepedia_1040	27770278	Homo sapiens	Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.	Glioblastoma cells	Protein	Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation	Extracellular vesicles	EVs
1015	Vesiclepedia_2923	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1016	Vesiclepedia_2940	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1017	Vesiclepedia_3097	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1018	Vesiclepedia_2542	34293122	Mus musculus	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein Lipid	Centrifugation	Extracellular vesicles	Large EVs
1019	Vesiclepedia_2221	34596356	Homo sapiens	Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer	Primary prostate stromal cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1020	Vesiclepedia_612	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1021	Vesiclepedia_2373	35087866	Rattus norvegicus	Exercise-Induced Extracellular Vesicles Delay the Progression of Prostate Cancer	Plasma	RNA	Size exclusion chromatography Filtration	Extracellular vesicles	Small EVs
1022	Vesiclepedia_2264	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1023	Vesiclepedia_2215	35953855	Bos taurus	Milk-derived small extracellular vesicles: nanomaterials to promote bone formation	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1024	Vesiclepedia_553	24009898	Mus musculus	Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.	Cardiomyocytes	mRNA	-	Exosomes/Extracellular vesicles	EVs
1025	Vesiclepedia_3301	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1026	Vesiclepedia_2869	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1027	Vesiclepedia_2846	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1028	Vesiclepedia_1603	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1029	Vesiclepedia_1619	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1030	Vesiclepedia_2554	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1031	Vesiclepedia_3545	36125881	Homo sapiens	Cell-free DNA topology depends on its subcellular and cellular origins in cancer	Plasma	mtDNA	-	Extracellular Vesicles	EVs
1032	Vesiclepedia_3470	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1033	Vesiclepedia_2387	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1034	Vesiclepedia_3040	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
1035	Vesiclepedia_2065	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1036	Vesiclepedia_3432	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1037	Vesiclepedia_2069	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1038	Vesiclepedia_2331	36635419	Homo sapiens	Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy	Fibroblasts	Protein mRNA	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1039	Vesiclepedia_1881	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1040	Vesiclepedia_1778	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1041	Vesiclepedia_1951	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1042	Vesiclepedia_1895	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1043	Vesiclepedia_570	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (CD63 PD)	Extracellular vesicles	EVs
1044	Vesiclepedia_1760	35918900	Homo sapiens	Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1045	Vesiclepedia_2192	35229476	Lactococcus lactis	Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage-encoded holin-lysin system	Lactococcus lactis	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1046	Vesiclepedia_1518	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1047	Vesiclepedia_2306	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1048	Vesiclepedia_2870	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1049	Vesiclepedia_3238	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1050	Vesiclepedia_844	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1051	Vesiclepedia_3297	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1052	Vesiclepedia_2937	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1053	Vesiclepedia_2092	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1054	Vesiclepedia_1929	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
1055	Vesiclepedia_1494	33991177	Homo sapiens	Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells	Gastric cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1056	Vesiclepedia_618	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1057	Vesiclepedia_2201	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1058	Vesiclepedia_1371	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
1059	Vesiclepedia_2265	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1060	Vesiclepedia_2433	29320704	Homo sapiens	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise	Plasma	Protein	Centrifugation	Extracellular vesicles	EVs
1061	Vesiclepedia_2896	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1062	Vesiclepedia_3173	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1063	Vesiclepedia_1728	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1064	Vesiclepedia_2012	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Centrifugation	Large extracellular vesicles	Large EVs
1065	Vesiclepedia_487	23230278	Homo sapiens	Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids.	Colorectal cancer cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
1066	Vesiclepedia_852	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1067	Vesiclepedia_2202	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1068	Vesiclepedia_2112	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1069	Vesiclepedia_2552	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1070	Vesiclepedia_2565	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1071	Vesiclepedia_2592	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1072	Vesiclepedia_1484	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1073	Vesiclepedia_521	23645497	Canis lupus familiaris	Oncogenic H-Ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition.	Kidney cells	Protein	-	Exosomes/Extracellular vesicles	EVs
1074	Vesiclepedia_1059	30006486	Homo sapiens	The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells.	Astrocytoma cells	Protein	Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1075	Vesiclepedia_2558	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1076	Vesiclepedia_1025	22327366	Homo sapiens	Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.	Vascular endothelial cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1077	Vesiclepedia_2702	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1078	Vesiclepedia_744	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
1079	Vesiclepedia_2203	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1080	Vesiclepedia_2093	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1081	Vesiclepedia_3226	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1082	Vesiclepedia_599	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1083	Vesiclepedia_2115	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient centrifugation	Small extracellular vesicles	Small EVs
1084	Vesiclepedia_2120	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1085	Vesiclepedia_1477	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1086	Vesiclepedia_1647	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1087	Vesiclepedia_1031	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	exoEasy columns	Extracellular vesicles	EVs
1088	Vesiclepedia_2891	28928431	Mus musculus	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90	Lung cancer cells	Protein	Centrifugal ultrafiltration ExoQuick Kit	Extracellular vesicles	EVs
1089	Vesiclepedia_2514	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1090	Vesiclepedia_2285	30863515	Homo sapiens	Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles	Lung epithelial cells	Protein Lipid	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1091	Vesiclepedia_1512	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1092	Vesiclepedia_1507	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1093	Vesiclepedia_1794	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1094	Vesiclepedia_1373	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
1095	Vesiclepedia_854	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1096	Vesiclepedia_2371	36759608	Homo sapiens	Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo	Stromal vascular fraction	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1097	Vesiclepedia_3429	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1098	Vesiclepedia_3461	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1099	Vesiclepedia_1901	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1100	Vesiclepedia_1889	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1101	Vesiclepedia_1403	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1102	Vesiclepedia_1411	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1103	Vesiclepedia_1130	23954818	Homo sapiens	Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.	Squamous carcinoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1104	Vesiclepedia_3296	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1105	Vesiclepedia_2090	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1106	Vesiclepedia_2213	37043568	Bos taurus	Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis	Bovine milk	miRNA	Differential centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1107	Vesiclepedia_2837	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1108	Vesiclepedia_2375	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	exoEasy Maxi Kit	Extracellular vesicles	Small EVs
1109	Vesiclepedia_3232	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1110	Vesiclepedia_1229	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
1111	Vesiclepedia_1516	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1112	Vesiclepedia_907	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer	Transitional papilloma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1113	Vesiclepedia_3472	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1114	Vesiclepedia_1860	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1115	Vesiclepedia_2368	36759608	Mus musculus	Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo	Adipocytes	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1116	Vesiclepedia_2722	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1117	Vesiclepedia_1859	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1118	Vesiclepedia_2363	36748335	Homo sapiens	Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α	Oral cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1119	Vesiclepedia_1869	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1120	Vesiclepedia_460	22745761	Paracoccidioides brasiliensis	Lipidomic Analysis of Extracellular Vesicles from the Pathogenic Phase of Paracoccidioides brasiliensis.	Paracoccidioides brasiliensis	Lipids	-	Extracellular vesicles	EVs
1121	Vesiclepedia_2611	30788085	Homo sapiens	Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma	Oral mucosa	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1122	Vesiclepedia_1266	24310399	Homo sapiens	Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1.	Glioblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	EVs
1123	Vesiclepedia_2809	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1124	Vesiclepedia_3394	31827089	Lactobacillus gasseri	Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues	Lactobacillus gasseri	Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1125	Vesiclepedia_3514	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1126	Vesiclepedia_2111	36482876	Mus musculus	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1127	Vesiclepedia_600	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Kidney cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1128	Vesiclepedia_3537	33420117	Homo sapiens	Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers	Serum	dsDNA	ExoQuick Kit	Extracellular Vesicles	EVs
1129	Vesiclepedia_2162	34140472	Ixodes ricinus	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Saliva	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1130	Vesiclepedia_1949	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1131	Vesiclepedia_651	29188495	Homo sapiens	Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.	Cerebrospinal fluid	Protein	Differential centrifugation Ultracentrifugation Sonication Filtration	Extracellular vesicles	EVs
1132	Vesiclepedia_3441	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1133	Vesiclepedia_1876	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1134	Vesiclepedia_2949	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1135	Vesiclepedia_2872	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	miRNA	Differential centrifugation Filtration ExoQuick Kit	Small extracellular vesicles	Small EVs
1136	Vesiclepedia_2721	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1137	Vesiclepedia_1206	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
1138	Vesiclepedia_1719	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1139	Vesiclepedia_1759	35918900	Homo sapiens	Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1140	Vesiclepedia_2825	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1141	Vesiclepedia_2713	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1142	Vesiclepedia_1304	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1143	Vesiclepedia_2097	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1144	Vesiclepedia_3495	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
1145	Vesiclepedia_3459	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Primary cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1146	Vesiclepedia_1990	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1147	Vesiclepedia_3486	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1148	Vesiclepedia_2303	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1149	Vesiclepedia_1753	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1150	Vesiclepedia_3215	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanocytes	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1151	Vesiclepedia_2194	29511463	Bos taurus	Biocompatibility of highly purified bovine milk-derived extracellular vesicles	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1152	Vesiclepedia_2372	35087866	Rattus norvegicus	Exercise-Induced Extracellular Vesicles Delay the Progression of Prostate Cancer	Plasma	RNA	Size exclusion chromatography Filtration	Extracellular vesicles	Small EVs
1153	Vesiclepedia_2875	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1154	Vesiclepedia_1418	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1155	Vesiclepedia_941	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1156	Vesiclepedia_2479	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1157	Vesiclepedia_1621	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1158	Vesiclepedia_2367	36759608	Mus musculus	Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo	Adipocytes	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1159	Vesiclepedia_1768	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1160	Vesiclepedia_488	23230278	Homo sapiens	Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids.	Colorectal cancer cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
1161	Vesiclepedia_1992	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1162	Vesiclepedia_3261	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Plasma	Protein miRNA	ExoQuick Kit	Small extracellular vesicles	EVs
1163	Vesiclepedia_1465	35054579	Gallus gallus	Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus	Trachea	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1164	Vesiclepedia_573	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (CD81 FT)	Extracellular vesicles	EVs
1165	Vesiclepedia_3403	31712780	Homo sapiens	Non-reversible tissue fixation retains extracellular vesicles for in situ imaging	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1166	Vesiclepedia_1758	35918900	Homo sapiens	Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1167	Vesiclepedia_1044	27770278	Homo sapiens	Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.	Glioblastoma cells	Protein	Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation	Extracellular vesicles	EVs
1168	Vesiclepedia_2214	37043568	Homo sapiens	Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis	Breast milk	miRNA	Differential centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1169	Vesiclepedia_2053	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1170	Vesiclepedia_3426	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1171	Vesiclepedia_3186	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1172	Vesiclepedia_2086	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1173	Vesiclepedia_1167	29907695	Mus musculus	Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.	Melanoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1174	Vesiclepedia_3390	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	-	Extracellular vesicles	Small EVs
1175	Vesiclepedia_3229	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1176	Vesiclepedia_983	25367658	Candida albicans	Proteomics unravels extracellular vesicles as carriers of classical cytoplasmic proteins in Candida albicans.	Candida albicans	Protein	Differential centrifugation Ultracentrifugation Filtration	Extracellular vesicles	EVs
1177	Vesiclepedia_3513	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1178	Vesiclepedia_1604	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1179	Vesiclepedia_2546	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1180	Vesiclepedia_3315	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1181	Vesiclepedia_2899	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1182	Vesiclepedia_1178	29854963	Homo sapiens	Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.	Urine	miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
1183	Vesiclepedia_1062	30006486	Homo sapiens	The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells.	Astrocytoma cells	Protein	Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1184	Vesiclepedia_1431	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1185	Vesiclepedia_1308	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1186	Vesiclepedia_2878	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Melanoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1187	Vesiclepedia_1875	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1188	Vesiclepedia_1632	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1189	Vesiclepedia_3497	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
1190	Vesiclepedia_3302	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1191	Vesiclepedia_2798	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small Evs
1192	Vesiclepedia_3039	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
1193	Vesiclepedia_3042	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
1194	Vesiclepedia_1747	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1195	Vesiclepedia_2369	36759608	Mus musculus	Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo	Adipocytes	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1196	Vesiclepedia_850	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1197	Vesiclepedia_1867	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1198	Vesiclepedia_1888	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1199	Vesiclepedia_2020	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1200	Vesiclepedia_2104	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1201	Vesiclepedia_2551	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1202	Vesiclepedia_1488	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Plasma	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1203	Vesiclepedia_1706	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
1204	Vesiclepedia_2597	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung epithelial cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1205	Vesiclepedia_3181	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1206	Vesiclepedia_2879	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Melanoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1207	Vesiclepedia_2686	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein	EVtrap	Extracellular vesicles	Small EVs
1208	Vesiclepedia_3450	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1209	Vesiclepedia_957	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1210	Vesiclepedia_3541	31596073	Homo sapiens	Isolation and Retrieval of Extracellular Vesicles for Liquid Biopsy of Malignant Ground-Glass Opacity	Plasma	dsDNA	Heparin/polymer-coated microspheres	Extracellular Vesicles	EVs
1211	Vesiclepedia_459	22745761	Paracoccidioides brasiliensis	Lipidomic Analysis of Extracellular Vesicles from the Pathogenic Phase of Paracoccidioides brasiliensis.	Paracoccidioides brasiliensis	Lipids	-	Extracellular vesicles	EVs
1212	Vesiclepedia_2840	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1213	Vesiclepedia_2596	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung epithelial cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1214	Vesiclepedia_2188	33792189	Mus musculus	A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions	Epididymal epithelial cells	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1215	Vesiclepedia_2789	35304471	Homo sapiens	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1216	Vesiclepedia_2449	34465793	Homo sapiens	Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer	Breast cancer cells	Protein miRNA	Centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1217	Vesiclepedia_1188	28326167	Homo sapiens	Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment.	Urine	Protein	Hydrostatic filtration dialysis Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1218	Vesiclepedia_3208	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1219	Vesiclepedia_3371	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Glioblastoma cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1220	Vesiclepedia_3354	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Retinal endothelial cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1221	Vesiclepedia_2017	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1222	Vesiclepedia_843	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1223	Vesiclepedia_2124	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1224	Vesiclepedia_1103	24408433	Prochlorococcus marinus	Bacterial vesicles in marine ecosystems.	Prochlorococcus marinus	Lipids	Ultrafiltration Density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1225	Vesiclepedia_3362	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Colorectal cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1226	Vesiclepedia_589	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1227	Vesiclepedia_3428	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1228	Vesiclepedia_2716	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1229	Vesiclepedia_585	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1230	Vesiclepedia_1741	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1231	Vesiclepedia_3086	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1232	Vesiclepedia_1723	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1233	Vesiclepedia_1589	33692129	Macaca fascicularis	Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	Mesenchymal stem cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1234	Vesiclepedia_1487	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1235	Vesiclepedia_2172	30536591	Homo sapiens	A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1236	Vesiclepedia_3205	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1237	Vesiclepedia_3359	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Breast cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1238	Vesiclepedia_3303	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1239	Vesiclepedia_1970	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
1240	Vesiclepedia_2889	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1241	Vesiclepedia_1862	35931686	Homo sapiens	Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression	Chondrocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1242	Vesiclepedia_1766	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1243	Vesiclepedia_2957	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1244	Vesiclepedia_1375	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
1245	Vesiclepedia_3177	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1246	Vesiclepedia_2169	29643357	Staphylococcus aureus	Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform	Staphylococcus aureus	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1247	Vesiclepedia_3247	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung epithelial cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1248	Vesiclepedia_940	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1249	Vesiclepedia_2064	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1250	Vesiclepedia_2402	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1251	Vesiclepedia_746	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
1252	Vesiclepedia_1426	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1253	Vesiclepedia_2415	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1254	Vesiclepedia_1774	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1255	Vesiclepedia_3420	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1256	Vesiclepedia_1002	24211404	Mus musculus	Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.	Lung tissue	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1257	Vesiclepedia_3466	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1258	Vesiclepedia_2105	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1259	Vesiclepedia_1793	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1260	Vesiclepedia_743	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
1261	Vesiclepedia_1954	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Plasma	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1262	Vesiclepedia_2123	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1263	Vesiclepedia_2413	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1264	Vesiclepedia_979	25471885	Drosophila melanogaster	The ESCRT machinery regulates the secretion and long-range activity of Hedgehog.	Drosophila wing imaginal Disc	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1265	Vesiclepedia_3299	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1266	Vesiclepedia_1914	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Colorectal cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1267	Vesiclepedia_3384	31732668	Rattus norvegicus	Label-free visualization and characterization of extracellular vesicles in breast cancer	Mammary epithelial cells	Metabolite	-	Extracellular vesicles	Small EVs
1268	Vesiclepedia_1630	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1269	Vesiclepedia_2574	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1270	Vesiclepedia_1606	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1271	Vesiclepedia_3448	32341770	Mus musculus	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Plasma	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1272	Vesiclepedia_3521	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1273	Vesiclepedia_3477	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1274	Vesiclepedia_2906	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1275	Vesiclepedia_2709	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1276	Vesiclepedia_1271	24058411	Homo sapiens	Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine.	Proximal tubular epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1277	Vesiclepedia_1784	35927827	Mus musculus	Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles	Dendritic cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1278	Vesiclepedia_1627	34012515	Homo sapiens	CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells	Melanoma cells	Protein Lipid	Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
1279	Vesiclepedia_3481	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1280	Vesiclepedia_921	28687758	Sus scrofa	Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers	Polarised retinal pigmented epithelial cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1281	Vesiclepedia_1612	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1282	Vesiclepedia_953	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1283	Vesiclepedia_1953	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Plasma	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1284	Vesiclepedia_1622	34796683	Homo sapiens	High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1285	Vesiclepedia_2058	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1286	Vesiclepedia_1637	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein Lipid	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1287	Vesiclepedia_1209	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
1288	Vesiclepedia_3209	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1289	Vesiclepedia_1947	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1290	Vesiclepedia_2948	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1291	Vesiclepedia_1483	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1292	Vesiclepedia_2600	35136055	Mus musculus	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1293	Vesiclepedia_2856	33579909	Homo sapiens	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1294	Vesiclepedia_2719	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1295	Vesiclepedia_1991	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1296	Vesiclepedia_1168	29907695	Mus musculus	Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.	Melanoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1297	Vesiclepedia_1803	35917363	Homo sapiens	CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1298	Vesiclepedia_1475	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
1299	Vesiclepedia_1578	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1300	Vesiclepedia_1707	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
1301	Vesiclepedia_3482	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1302	Vesiclepedia_2882	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Serum	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1303	Vesiclepedia_2273	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
1304	Vesiclepedia_2733	35545056	Mus musculus	MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	Bone marrow cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1305	Vesiclepedia_2360	36708245	Homo sapiens	Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases	Blood	Protein Lipid	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1306	Vesiclepedia_1063	30006486	Homo sapiens	The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells.	Astrocytoma cells	Protein	Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1307	Vesiclepedia_1191	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1308	Vesiclepedia_1731	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1309	Vesiclepedia_2358	36708245	Homo sapiens	Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases	Blood	Protein Lipid	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1310	Vesiclepedia_2286	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Natural killer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
1311	Vesiclepedia_2699	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1312	Vesiclepedia_2293	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Prostate cancer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
1313	Vesiclepedia_3326	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1314	Vesiclepedia_3260	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Plasma	Protein miRNA	ExoQuick Kit	Small extracellular vesicles	EVs
1315	Vesiclepedia_620	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1316	Vesiclepedia_2782	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Hypertrophic chondrocytes	Protein	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1317	Vesiclepedia_1740	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1318	Vesiclepedia_1764	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1319	Vesiclepedia_3445	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1320	Vesiclepedia_2228	32494663	Homo sapiens	miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1	Pancreatic cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1321	Vesiclepedia_3517	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1322	Vesiclepedia_2599	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1323	Vesiclepedia_3300	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1324	Vesiclepedia_1391	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein	Centrifugation Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1325	Vesiclepedia_1470	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1326	Vesiclepedia_1610	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1327	Vesiclepedia_1892	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1328	Vesiclepedia_2441	36591510	Homo sapiens	Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1329	Vesiclepedia_2818	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1330	Vesiclepedia_2962	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1331	Vesiclepedia_1713	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1332	Vesiclepedia_1916	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Gastric cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1333	Vesiclepedia_1765	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1334	Vesiclepedia_1398	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1335	Vesiclepedia_1903	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1336	Vesiclepedia_3234	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1337	Vesiclepedia_2480	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1338	Vesiclepedia_1399	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1339	Vesiclepedia_747	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
1340	Vesiclepedia_485	23214914	Trypanosoma cruzi	Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.	Metacyclic trypomastigotes	Protein	-	Exosomes/Extracellular vesicles/Ectosomes	EVs
1341	Vesiclepedia_1915	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Colorectal cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1342	Vesiclepedia_1611	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1343	Vesiclepedia_2568	35260554	Homo sapiens	Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis	Gastric cancer cells	Protein mRNA	Centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1344	Vesiclepedia_1503	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1345	Vesiclepedia_2089	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1346	Vesiclepedia_1466	35054579	Gallus gallus	Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus	Trachea	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1347	Vesiclepedia_610	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1348	Vesiclepedia_1761	35918900	Homo sapiens	Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1349	Vesiclepedia_1034	29887978	Homo sapiens	Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.	Serum	Protein miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
1350	Vesiclepedia_2260	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1351	Vesiclepedia_3388	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	-	Extracellular vesicles	Small EVs
1352	Vesiclepedia_2133	36515353	Homo sapiens	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	Plasma	Metabolite Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
1353	Vesiclepedia_1597	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1354	Vesiclepedia_2529	34293122	Homo sapiens	Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules	Platelets	Protein Lipid	Centrifugation	Extracellular vesicles	Large EVs
1355	Vesiclepedia_3444	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1356	Vesiclepedia_2560	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1357	Vesiclepedia_935	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1358	Vesiclepedia_1163	29904572	Bos taurus	A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk.	Bovine milk	Protein miRNA	Differential centrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1359	Vesiclepedia_2684	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic duct epithelial cells	Protein	EVtrap	Extracellular vesicles	Small EVs
1360	Vesiclepedia_1748	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1361	Vesiclepedia_2496	34368811	Homo sapiens	Isolation and characterization of extracellular vesicles in saliva of children with asthma	Saliva	Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	EVs
1362	Vesiclepedia_2287	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Natural killer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
1363	Vesiclepedia_1169	29907695	Mus musculus	Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.	Melanoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1364	Vesiclepedia_2594	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1365	Vesiclepedia_1724	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1366	Vesiclepedia_1180	29854963	Homo sapiens	Genome-wide Profiling of Urinary Extracellular Vesicle microRNAs Associated With Diabetic Nephropathy in Type 1 Diabetes.	Urine	miRNA	qEV size-exclusion column	Extracellular vesicles	EVs
1367	Vesiclepedia_847	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1368	Vesiclepedia_2841	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1369	Vesiclepedia_1898	36260670	Mus musculus	Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice	Plasma	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1370	Vesiclepedia_3091	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1371	Vesiclepedia_3389	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	-	Extracellular vesicles	Small EVs
1372	Vesiclepedia_1379	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1373	Vesiclepedia_3578	31596073	Homo sapiens	Isolation and Retrieval of Extracellular Vesicles for Liquid Biopsy of Malignant Ground-Glass Opacity	Plasma	dsDNA-mutated	Heparin/polymer-coated microspheres	Extracellular Vesicles	EVs
1374	Vesiclepedia_2604	35654787	Homo sapiens	CircSCAF8 promotes growth and metastasis of prostate cancer through the circSCAF8-miR-140-3p/miR-335-LIF pathway	Urine	circRNA	Differential centrifugation Ultracentrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1375	Vesiclepedia_1394	32939236	Homo sapiens	Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection	Saliva	Protein Lipid	Differential centrifugation Tangential flow filtration Size exclusion chromatography	Extracellular vesicles	Small EVs
1376	Vesiclepedia_1174	29881354	Rattus norvegicus	Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content.	Serum	Protein miRNA	ExoQuick	Extracellular vesicles	EVs
1377	Vesiclepedia_3431	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1378	Vesiclepedia_461	22848702	Homo sapiens	Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles.	Medulloblastoma cells	Protein	-	Exosomes/Membrane vesicles/Extracellular vesicles	EVs
1379	Vesiclepedia_1981	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1380	Vesiclepedia_1917	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Gastric cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1381	Vesiclepedia_1061	30006486	Homo sapiens	The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells.	Astrocytoma cells	Protein	Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1382	Vesiclepedia_2077	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1383	Vesiclepedia_2588	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1384	Vesiclepedia_2834	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1385	Vesiclepedia_2893	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1386	Vesiclepedia_1925	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1387	Vesiclepedia_1214	29127410	Homo sapiens	Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.	Bronchial epithelial cells	Protein	Ultracentrifugation	Extracellular vesicles	EVs
1388	Vesiclepedia_2212	37043568	Homo sapiens	Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis	Breast milk	Protein	Differential centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1389	Vesiclepedia_985	25287304	Candida albicans	Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans.	Candida albicans	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1390	Vesiclepedia_1519	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Mast cells	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1391	Vesiclepedia_2434	29320704	Homo sapiens	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise	Plasma	Protein	Centrifugation	Extracellular vesicles	EVs
1392	Vesiclepedia_1508	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1393	Vesiclepedia_2852	33579909	Homo sapiens	Sulfisoxazole does not inhibit the secretion of small extracellular vesicles	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1394	Vesiclepedia_2139	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1395	Vesiclepedia_1968	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation Sucrose density gradient centrifugation	Extracellular vesicles	Small EVs
1396	Vesiclepedia_511	23521563	Homo sapiens	First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.	Ewing's sarcoma cells	mRNA	-	Exosomes/Extracellular vesicles	EVs
1397	Vesiclepedia_1514	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1398	Vesiclepedia_3446	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1399	Vesiclepedia_1772	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1400	Vesiclepedia_1495	33991177	Homo sapiens	Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells	Gastric cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1401	Vesiclepedia_2710	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1402	Vesiclepedia_580	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1403	Vesiclepedia_3479	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1404	Vesiclepedia_2868	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1405	Vesiclepedia_3309	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1406	Vesiclepedia_3581	31232418	Homo sapiens	Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica	Plasma	dsDNA-mutated	Lipid nanoprobe functionalized nanostructured silica platform	Extracellular Vesicles	EVs
1407	Vesiclepedia_2577	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1408	Vesiclepedia_2946	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1409	Vesiclepedia_874	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	miRNA	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
1410	Vesiclepedia_2380	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1411	Vesiclepedia_1587	33692129	Macaca fascicularis	Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	Mesenchymal stem cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
1412	Vesiclepedia_3320	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1413	Vesiclepedia_2735	35545056	Mus musculus	MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	Bone marrow cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1414	Vesiclepedia_575	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Breast cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1415	Vesiclepedia_1464	35054579	Gallus gallus	Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus	Trachea	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1416	Vesiclepedia_2404	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1417	Vesiclepedia_3490	31278254	Mus musculus	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1418	Vesiclepedia_2509	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	EVs
1419	Vesiclepedia_1497	33991177	Homo sapiens	Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells	Gastric cancer cells	Protein	Differential centrifugation Ultracentrifugation	Large extracellular vesicles	Large EVs
1420	Vesiclepedia_1560	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1421	Vesiclepedia_3419	33391636	Homo sapiens	Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus	Embryonic kidney cells	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1422	Vesiclepedia_1982	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1423	Vesiclepedia_2130	36515353	Homo sapiens	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	Plasma	Metabolite Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
1424	Vesiclepedia_2305	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1425	Vesiclepedia_3102	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1426	Vesiclepedia_895	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1427	Vesiclepedia_3553	27305142	Homo sapiens	Comparative Study of Extracellular Vesicles from the Urine of Healthy Individuals and Prostate Cancer Patients	Urine	dsDNA	Ultracentrifugation	Extracellular Vesicles	EVs
1428	Vesiclepedia_2505	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Large EVs
1429	Vesiclepedia_2038	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1430	Vesiclepedia_936	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1431	Vesiclepedia_1739	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1432	Vesiclepedia_2566	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1433	Vesiclepedia_583	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1434	Vesiclepedia_522	23645497	Canis lupus familiaris	Oncogenic H-Ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition.	Kidney cells	Protein	-	Exosomes/Extracellular vesicles	EVs
1435	Vesiclepedia_1412	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1436	Vesiclepedia_1592	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1437	Vesiclepedia_2023	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1438	Vesiclepedia_1591	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1439	Vesiclepedia_1301	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1440	Vesiclepedia_1733	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1441	Vesiclepedia_3416	33391636	Homo sapiens	Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus	Lung cancer cells	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1442	Vesiclepedia_2897	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Esophageal cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1443	Vesiclepedia_2717	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1444	Vesiclepedia_2902	33732415	Homo sapiens	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Pancreatic cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1445	Vesiclepedia_1942	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1446	Vesiclepedia_2812	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1447	Vesiclepedia_2127	36649440	Homo sapiens	Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells	Brain endothelial cells	Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
1448	Vesiclepedia_2262	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1449	Vesiclepedia_1652	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1450	Vesiclepedia_2052	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1451	Vesiclepedia_2510	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1452	Vesiclepedia_1557	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1453	Vesiclepedia_2951	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1454	Vesiclepedia_2319	31762962	Homo sapiens	Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers	Plasma	Protein small RNA	ExoQuick Kit	Extracellular vesicles/Exosomes	EVs
1455	Vesiclepedia_1955	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1456	Vesiclepedia_3090	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1457	Vesiclepedia_1352	32938681	Homo sapiens	Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis	Smooth muscle cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1458	Vesiclepedia_867	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
1459	Vesiclepedia_3084	35665306	Mus musculus	Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles	Serum	Protein	Size exclusion chromatography Ultracentrifugation	Extracellular vesicles	Small EVs
1460	Vesiclepedia_3328	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1461	Vesiclepedia_2016	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Vascular smooth muscle cells	Protein	Differential centrifugation	Medium extracellular vesicles	Large EVs
1462	Vesiclepedia_943	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1463	Vesiclepedia_2945	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1464	Vesiclepedia_1858	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1465	Vesiclepedia_1413	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1466	Vesiclepedia_2585	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1467	Vesiclepedia_2518	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
1468	Vesiclepedia_1556	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1469	Vesiclepedia_892	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1470	Vesiclepedia_1908	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1471	Vesiclepedia_1428	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1472	Vesiclepedia_2204	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1473	Vesiclepedia_2129	36515353	Homo sapiens	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	Plasma	Protein	ExoQuick Kit Centrifugation	Extracellular vesicles	Small EVs
1474	Vesiclepedia_3245	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1475	Vesiclepedia_3451	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1476	Vesiclepedia_2173	30536591	Homo sapiens	A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1477	Vesiclepedia_1378	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral epithelial cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
1478	Vesiclepedia_2110	36482876	Mus musculus	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1479	Vesiclepedia_2950	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1480	Vesiclepedia_608	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1481	Vesiclepedia_1944	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1482	Vesiclepedia_551	24009886	Homo sapiens	Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes.	Endothelial cells	Protein	-	Exosomes/Extracellular vesicles	EVs
1483	Vesiclepedia_2515	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1484	Vesiclepedia_1643	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1485	Vesiclepedia_2289	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Neuroblastoma cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
1486	Vesiclepedia_1028	26378940	Homo sapiens	Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1487	Vesiclepedia_2436	29320704	Homo sapiens	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise	Plasma	Protein	Centrifugation	Extracellular vesicles	EVs
1488	Vesiclepedia_621	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Melanoma cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1489	Vesiclepedia_2732	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1490	Vesiclepedia_2965	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1491	Vesiclepedia_2406	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1492	Vesiclepedia_1307	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1493	Vesiclepedia_1641	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1494	Vesiclepedia_1410	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1495	Vesiclepedia_1952	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1496	Vesiclepedia_3262	34654817	Rattus norvegicus	Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors	Plasma	miRNA	ExoQuick Kit	Small extracellular vesicles	EVs
1497	Vesiclepedia_609	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Lung cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1498	Vesiclepedia_905	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer	Bladder cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1499	Vesiclepedia_2268	36624553	Homo sapiens	Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles	Plasma	Protein	Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration	Small extracellular vesicles	Small EVs
1500	Vesiclepedia_1940	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1501	Vesiclepedia_3228	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1502	Vesiclepedia_1910	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1503	Vesiclepedia_870	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
1504	Vesiclepedia_1489	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Plasma	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1505	Vesiclepedia_1642	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Primary cortical neurons	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1506	Vesiclepedia_3095	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1507	Vesiclepedia_2025	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Osteosarcoma cells	Protein	Differential centrifugation	Medium extracellular vesicles	Large EVs
1508	Vesiclepedia_2024	36433666	Homo sapiens	Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization	Osteosarcoma cells	Protein	Centrifugation	Large extracellular vesicles	Large EVs
1509	Vesiclepedia_2403	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1510	Vesiclepedia_1417	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1511	Vesiclepedia_2365	36748335	Homo sapiens	Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α	Oral cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1512	Vesiclepedia_2071	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1513	Vesiclepedia_3471	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ovarian cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1514	Vesiclepedia_2824	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1515	Vesiclepedia_3294	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1516	Vesiclepedia_2586	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1517	Vesiclepedia_2074	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1518	Vesiclepedia_1302	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1519	Vesiclepedia_962	26047123	Bos taurus	Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models.	Bovine milk	mRNA	Differential centrifugation Ultracentrifugation Filtration	Extracellular vesicles	EVs
1520	Vesiclepedia_1224	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Exo-spin	Extracellular vesicles	EVs
1521	Vesiclepedia_2849	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1522	Vesiclepedia_2681	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1523	Vesiclepedia_2294	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Cervical cancer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
1524	Vesiclepedia_1311	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1525	Vesiclepedia_3557	23580760	Homo sapiens	Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells	Vascular smooth muscle cells	dsDNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1526	Vesiclepedia_1424	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1527	Vesiclepedia_1734	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1528	Vesiclepedia_593	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1529	Vesiclepedia_2506	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1530	Vesiclepedia_2815	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein mRNA miRNA tRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1531	Vesiclepedia_3502	31160588	Homo sapiens	Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2	Platelets	Protein	Differential centrifugation	Extracellular vesicles	EVs
1532	Vesiclepedia_888	24946052	Homo sapiens	Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1533	Vesiclepedia_550	24009881	Homo sapiens	Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells.	Colorectal cancer cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles/Ectosomes	EVs
1534	Vesiclepedia_1712	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1535	Vesiclepedia_2114	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1536	Vesiclepedia_1609	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1537	Vesiclepedia_1351	32938681	Homo sapiens	Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis	Smooth muscle cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1538	Vesiclepedia_2063	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1539	Vesiclepedia_875	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	miRNA	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
1540	Vesiclepedia_2386	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1541	Vesiclepedia_2820	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1542	Vesiclepedia_1738	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1543	Vesiclepedia_3522	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1544	Vesiclepedia_2739	35513391	Homo sapiens	Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1	Posterior longitudinal ligament	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1545	Vesiclepedia_2707	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1546	Vesiclepedia_3382	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1547	Vesiclepedia_2680	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1548	Vesiclepedia_1945	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1549	Vesiclepedia_2035	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1550	Vesiclepedia_3468	35393416	Homo sapiens	CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity	Oral cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1551	Vesiclepedia_3188	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1552	Vesiclepedia_2295	30891164	Homo sapiens	Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells	Liver cancer cells	Protein	Polyethylene glycol-based precipitation Centrifugation Dialysis	Extracellular vesicles	Small EVs
1553	Vesiclepedia_3193	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1554	Vesiclepedia_2844	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1555	Vesiclepedia_2862	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Mammary epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1556	Vesiclepedia_1770	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1557	Vesiclepedia_3385	31732668	Rattus norvegicus	Label-free visualization and characterization of extracellular vesicles in breast cancer	Breast cancer cells	Metabolite	-	Extracellular vesicles	Small EVs
1558	Vesiclepedia_1517	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1559	Vesiclepedia_3100	36631249	Homo sapiens	S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos	Liver cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1560	Vesiclepedia_2034	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1561	Vesiclepedia_1718	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1562	Vesiclepedia_2284	30863515	Homo sapiens	Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles	Lung epithelial cells	Protein Lipid	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1563	Vesiclepedia_1598	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1564	Vesiclepedia_2099	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1565	Vesiclepedia_749	29988836	Homo sapiens	Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine	Urine	Protein	Filtration Size exclusion chromatography	Extracellular vesicles	EVs
1566	Vesiclepedia_2144	36658400	Mus musculus	Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1567	Vesiclepedia_2478	34401050	Homo sapiens	TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	Hepatocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1568	Vesiclepedia_2964	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1569	Vesiclepedia_3535	36289852	Homo sapiens	Sequencing Comparative Analysis of DNA Mutations between Blood-Derived Extracellular Vesicles and Matched Cancer Tissue in Patients with Grade 4 Glioblastoma	Plasma	dsDNA	ExoEasy Maxi Kit	Extracellular Vesicles	EVs
1570	Vesiclepedia_584	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Brain cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1571	Vesiclepedia_1476	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Serum	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1572	Vesiclepedia_2508	34322205	Homo sapiens	Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	Monocytic leukemia cells	Protein	Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	EVs
1573	Vesiclepedia_1856	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1574	Vesiclepedia_545	23983189	Homo sapiens	Characterization of Multiple Myeloma Vesicles by Label-Free Relative Quantitation.	B cells	Protein	-	Exosomes/Extracellular vesicles/Microvesicles	EVs
1575	Vesiclepedia_848	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1576	Vesiclepedia_2308	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1577	Vesiclepedia_1170	29907695	Mus musculus	Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.	Melanoma cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1578	Vesiclepedia_2304	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	Monocytes	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1579	Vesiclepedia_2068	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1580	Vesiclepedia_3341	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Plasma	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1581	Vesiclepedia_2886	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1582	Vesiclepedia_1727	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration Size exclusion chromatography	Extracellular vesicles	EVs
1583	Vesiclepedia_1585	33692129	Macaca fascicularis	Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates	Mesenchymal stem cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Small extracellular vesicles	Small EVs
1584	Vesiclepedia_1964	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1585	Vesiclepedia_1849	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1586	Vesiclepedia_1973	35915084	Mus musculus	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1587	Vesiclepedia_1980	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1588	Vesiclepedia_3305	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1589	Vesiclepedia_1786	35927827	Mus musculus	Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles	Dendritic cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1590	Vesiclepedia_3206	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1591	Vesiclepedia_1846	36068649	Mus musculus	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Colorectal cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1592	Vesiclepedia_1573	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1593	Vesiclepedia_2544	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1594	Vesiclepedia_2165	34140472	Ixodes scapularis	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Salivary glands	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1595	Vesiclepedia_2075	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1596	Vesiclepedia_2168	29643357	Staphylococcus aureus	Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform	Staphylococcus aureus	Protein	Filtration Tangential flow filtration OptiPrep density gradient centrifugation Ultracentrifugation Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1597	Vesiclepedia_2930	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1598	Vesiclepedia_547	24009880	Homo sapiens	Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.	Mast cells	miRNA	-	Exosomes/Extracellular vesicles	EVs
1599	Vesiclepedia_2835	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1600	Vesiclepedia_1407	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1601	Vesiclepedia_2036	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1602	Vesiclepedia_1490	32024826	Homo sapiens	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Plasma	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1603	Vesiclepedia_2193	29511463	Bos taurus	Biocompatibility of highly purified bovine milk-derived extracellular vesicles	Bovine milk	Protein	Acidification Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1604	Vesiclepedia_1623	34796683	Homo sapiens	High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake	Breast cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1605	Vesiclepedia_2259	35661560	Homo sapiens	Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells	Plasma	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1606	Vesiclepedia_2108	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1607	Vesiclepedia_3393	31827089	Lactobacillus gasseri	Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues	Lactobacillus gasseri	Protein Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1608	Vesiclepedia_1510	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1609	Vesiclepedia_1369	33144925	Homo sapiens	Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer	Oral cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Total Exosome Isolation Reagent	Extracellular vesicles	Small EVs
1610	Vesiclepedia_2095	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1611	Vesiclepedia_2871	30918259	Homo sapiens	Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A	Breast cancer cells	miRNA	Differential centrifugation Filtration ExoQuick Kit	Small extracellular vesicles	Small EVs
1612	Vesiclepedia_2956	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1613	Vesiclepedia_2610	30788085	Homo sapiens	Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma	Oral mucosa	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1614	Vesiclepedia_2399	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1615	Vesiclepedia_1650	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1616	Vesiclepedia_1353	32938681	Homo sapiens	Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis	Valvular interstitial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1617	Vesiclepedia_2598	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1618	Vesiclepedia_1602	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1619	Vesiclepedia_3456	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Fibroblasts	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1620	Vesiclepedia_3460	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Dermal fibroblast cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1621	Vesiclepedia_2573	35689797	Homo sapiens	Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations	Mammary epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1622	Vesiclepedia_3331	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colon epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1623	Vesiclepedia_1184	28684402	Homo sapiens	BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells	Melanoma cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	EVs
1624	Vesiclepedia_2813	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1625	Vesiclepedia_2943	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1626	Vesiclepedia_1513	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	miRNA	ExoQuick Kit	Extracellular vesicles	Small EVs
1627	Vesiclepedia_1552	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1628	Vesiclepedia_1788	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Primary cortical neurons	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1629	Vesiclepedia_1865	35931686	Homo sapiens	Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression	Chondrocytes	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1630	Vesiclepedia_2567	33805332	Bos taurus	Temporal Quantitative Proteomics Analysis of Neuroblastoma Cells Treated with Bovine Milk-Derived Extracellular Vesicles Highlights the Anti-Proliferative Properties of Milk-Derived Extracellular Vesicles	Bovine milk	Protein	Differential centrifugation Ultracentrifugation Filtration	Extracellular vesicles	Small EVs
1631	Vesiclepedia_2685	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic duct epithelial cells	Protein	EVtrap	Extracellular vesicles	Small EVs
1632	Vesiclepedia_3038	33893753	Homo sapiens	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy	Fibroblasts	Protein	Centrifugation Polyethylene glycol-based precipitation	Extracellular vesicles	EVs
1633	Vesiclepedia_3344	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Pancreatic cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1634	Vesiclepedia_3524	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1635	Vesiclepedia_3259	34580290	Mus musculus	Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles	Kidney medullary cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1636	Vesiclepedia_2395	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1637	Vesiclepedia_1173	29881354	Rattus norvegicus	Effects of Acute Aerobic Exercise on Rats Serum Extracellular Vesicles Diameter, Concentration and Small RNAs Content.	Serum	Protein miRNA	ExoQuick	Extracellular vesicles	EVs
1638	Vesiclepedia_2683	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein Lipid Metabolite	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1639	Vesiclepedia_1870	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1640	Vesiclepedia_2559	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1641	Vesiclepedia_3528	30948809	Homo sapiens	Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers	Plasma	Protein	Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1642	Vesiclepedia_2708	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1643	Vesiclepedia_1893	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1644	Vesiclepedia_2037	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1645	Vesiclepedia_1851	36068649	Homo sapiens	Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway	Plasma	Protein	Centrifugation Filtration Exo-spin midi Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1646	Vesiclepedia_2845	35058437	Homo sapiens	Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1647	Vesiclepedia_1580	33785738	Mus musculus	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1648	Vesiclepedia_3222	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1649	Vesiclepedia_1872	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Plasma	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1650	Vesiclepedia_1018	22399603	Homo sapiens	Proteomic analysis of exosome-like vesicles derived from breast cancer cells.	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1651	Vesiclepedia_1481	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1652	Vesiclepedia_1430	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1653	Vesiclepedia_3192	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1654	Vesiclepedia_1967	35915084	Mus musculus	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1655	Vesiclepedia_2941	35106941	Cricetulus griseus	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Ovarian epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1656	Vesiclepedia_3183	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1657	Vesiclepedia_2493	34370714	Homo sapiens	MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression	Serum	miRNA	Polyethylene glycol-based precipitation Centrifugation	Extracellular vesicles	EVs
1658	Vesiclepedia_3175	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1659	Vesiclepedia_374	18039940	Cryptococcus neoformans	Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence.	Cryptococcus neoformans	Protein	-	Exosomes/Extracellular vesicles	EVs
1660	Vesiclepedia_3212	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1661	Vesiclepedia_1427	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1662	Vesiclepedia_3511	31068461	Homo sapiens	Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1663	Vesiclepedia_1232	25475747	Homo sapiens	Identification of Biomarkers for PKD1 Using Urinary Exosomes	Urine	Protein	Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1664	Vesiclepedia_2909	33732415	Mus musculus	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Lung cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1665	Vesiclepedia_629	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Ovarian cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1666	Vesiclepedia_1409	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1667	Vesiclepedia_3532	30936474	Homo sapiens	Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells	Macrophage	Protein	Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1668	Vesiclepedia_1742	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Cerebrospinal fluid	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1669	Vesiclepedia_3383	31732668	Homo sapiens	Label-free visualization and characterization of extracellular vesicles in breast cancer	Mammary epithelial cells	Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1670	Vesiclepedia_1777	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1671	Vesiclepedia_2718	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1672	Vesiclepedia_1425	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1673	Vesiclepedia_2378	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1674	Vesiclepedia_1181	28684402	Homo sapiens	BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells	Melanoma cells	miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	EVs
1675	Vesiclepedia_3169	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1676	Vesiclepedia_3311	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1677	Vesiclepedia_3391	31827089	Lactobacillus crispatus	Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues	Lactobacillus crispatus	Metabolite	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1678	Vesiclepedia_3372	33510128	Mus musculus	Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1679	Vesiclepedia_1354	32938681	Homo sapiens	Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis	Valvular interstitial cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1680	Vesiclepedia_869	24614226	Ovis aries	Extracellular vesicles in luminal fluid of the ovine uterus	Uterine luminal fluid	Protein	Differential centrifugation Filtration ExoQuick	Extracellular vesicles	EVs
1681	Vesiclepedia_3185	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1682	Vesiclepedia_2581	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1683	Vesiclepedia_2826	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1684	Vesiclepedia_3510	31068461	Mus musculus	Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1685	Vesiclepedia_2903	33732415	Mus musculus	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Lung cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1686	Vesiclepedia_2054	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1687	Vesiclepedia_3111	30967557	Mus musculus	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a	Hippocampal neuronal cells	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1688	Vesiclepedia_1226	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
1689	Vesiclepedia_3579	33692304	Homo sapiens	Use of Liquid Biopsy to Detect PIK3CA Mutation in Metastatic Breast Cancer	Plasma	dsDNA-mutated	Exosome Isolation Kit	Extracellular Vesicles	EVs
1690	Vesiclepedia_1305	-	Saccharomyces cerevisiae	Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling	Saccharomyces cerevisiae	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1691	Vesiclepedia_2806	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1692	Vesiclepedia_3221	34957415	Mus musculus	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1693	Vesiclepedia_2109	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1694	Vesiclepedia_2313	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	T cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1695	Vesiclepedia_1749	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Plasma	Protein	Centrifugal filtration OptiPrep density gradient centrifugation	Extracellular vesicles	EVs
1696	Vesiclepedia_1601	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1697	Vesiclepedia_1907	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1698	Vesiclepedia_3404	31712780	Bos taurus	Non-reversible tissue fixation retains extracellular vesicles for in situ imaging	Vitreous	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1699	Vesiclepedia_1871	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Plasma	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1700	Vesiclepedia_2823	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1701	Vesiclepedia_938	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1702	Vesiclepedia_1978	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1703	Vesiclepedia_937	29207636	Homo sapiens	Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.	Urine	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1704	Vesiclepedia_1943	36604402	Homo sapiens	Identification of faecal extracellular vesicles as novel biomarkers for the non-invasive diagnosis and prognosis of colorectal cancer	Faeces	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1705	Vesiclepedia_2163	34140472	Homo sapiens	Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection	Leukemia cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1706	Vesiclepedia_3306	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1707	Vesiclepedia_3378	36581870	Mus musculus	Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway	Colon cancer cells	Protein	Differential centrifugation Ultracentrifugation Qiagen Exosome Purification Kit	Extracellular vesicles	EVs
1708	Vesiclepedia_2821	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1709	Vesiclepedia_3351	34887515	Homo sapiens	Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	Colorectal cancer cells	Protein	Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation	Small extracellular vesicles	Small EVs
1710	Vesiclepedia_590	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Colorectal cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1711	Vesiclepedia_2703	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1712	Vesiclepedia_1482	32024826	Mus musculus	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload	Hepatocytes	Protein miRNA	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1713	Vesiclepedia_554	24009898	Mus musculus	Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.	Cardiomyocytes	mRNA	-	Exosomes/Extracellular vesicles	EVs
1714	Vesiclepedia_1555	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Centrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1715	Vesiclepedia_1400	35165262	Homo sapiens	DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer	Colon cancer cells	Protein	Differential centrifugation Tangential flow filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1716	Vesiclepedia_2066	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1717	Vesiclepedia_1420	36706192	Homo sapiens	Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles	Embryonic kidney cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1718	Vesiclepedia_1906	36266345	Homo sapiens	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression	Fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1719	Vesiclepedia_2084	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Macrophage	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1720	Vesiclepedia_1868	36063142	Mus musculus	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Embryonic fibroblasts	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1721	Vesiclepedia_3483	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1722	Vesiclepedia_1937	36193887	Homo sapiens	Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1723	Vesiclepedia_846	28881726	Homo sapiens	Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer	Prostate cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1724	Vesiclepedia_1979	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Plasma	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1725	Vesiclepedia_2954	31101910	Homo sapiens	Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death	Monocytes	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1726	Vesiclepedia_2355	36708245	Homo sapiens	Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases	Faeces	Protein Lipid	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1727	Vesiclepedia_3189	34743199	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lymphoma cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Extracellular vesicles	Small EVs
1728	Vesiclepedia_954	27601599	Homo sapiens	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	Breast milk	Protein	Differential centrifugation Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1729	Vesiclepedia_2926	35106941	Homo sapiens	K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis	Human embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	EVs
1730	Vesiclepedia_1496	33991177	Homo sapiens	Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells	Gastric cancer cells	Protein	Differential centrifugation Ultracentrifugation	Large extracellular vesicles	Large EVs
1731	Vesiclepedia_1790	36594832	Mus musculus	Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia	Neuroblastoma cells	miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1732	Vesiclepedia_572	26858453	Homo sapiens	Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes	Dendritic cells	Protein	Differential centrifugation Ultracentrifugation Immunobeads (CD81 PD)	Extracellular vesicles	EVs
1733	Vesiclepedia_1709	34092791	Homo sapiens	L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma	Induced pluripotent stem cell-derived neurons	Protein	Differential centrifugation Ultracentrifugation Size exclusion chromatography	Extracellular vesicles	EVs
1734	Vesiclepedia_1926	36214496	Homo sapiens	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Embryonic kidney cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1735	Vesiclepedia_3434	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1736	Vesiclepedia_2315	31489147	Homo sapiens	Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles	T cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1737	Vesiclepedia_2040	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1738	Vesiclepedia_3233	34596365	Homo sapiens	Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1739	Vesiclepedia_1390	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1740	Vesiclepedia_2691	35656858	Homo sapiens	A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells	Pancreatic cancer cells	Protein	EVtrap	Extracellular vesicles	Small EVs
1741	Vesiclepedia_3439	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1742	Vesiclepedia_3237	34596365	Homo sapiens	CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles	Lung cancer cells	miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1743	Vesiclepedia_1921	36303008	Homo sapiens	A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	Lung cancer cells	Protein	Filtration Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1744	Vesiclepedia_2816	34168137	Bos taurus	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Bovine milk	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1745	Vesiclepedia_2388	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1746	Vesiclepedia_2564	31819794	Homo sapiens	Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1747	Vesiclepedia_3478	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1748	Vesiclepedia_3313	32139701	Homo sapiens	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1749	Vesiclepedia_2060	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1750	Vesiclepedia_3292	32848136	Homo sapiens	ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells	Breast cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1751	Vesiclepedia_2198	33732416	Homo sapiens	Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	Breast milk	Protein	Differential centrifugation OptiPrep density gradient centrifugation Size exclusion chromatography	Extracellular vesicles	Small EVs
1752	Vesiclepedia_3218	34957415	Homo sapiens	Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism	Melanoma cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1753	Vesiclepedia_3476	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1754	Vesiclepedia_1879	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Plasma	Protein	Differential centrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1755	Vesiclepedia_1506	33953168	Homo sapiens	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation	Serum	Protein	Centrifugation Filtration Iodixanol density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1756	Vesiclepedia_1896	36260670	Mus musculus	Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice	Mesenchymal stem cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1757	Vesiclepedia_1595	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1758	Vesiclepedia_2705	35333565	Homo sapiens	LAMP2A regulates the loading of proteins into exosomes	Retinal pigment epithelial cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1759	Vesiclepedia_2584	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung epithelial cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1760	Vesiclepedia_1624	34012515	Homo sapiens	CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells	Melanoma cells	Protein	Differential centrifugation Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	EVs
1761	Vesiclepedia_2603	35654787	Homo sapiens	CircSCAF8 promotes growth and metastasis of prostate cancer through the circSCAF8-miR-140-3p/miR-335-LIF pathway	Urine	circRNA	Differential centrifugation Ultracentrifugation ExoQuick Kit	Extracellular vesicles	Small EVs
1762	Vesiclepedia_3421	32341770	Homo sapiens	DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination	Pancreatic cancer cells	Protein	Centrifugal ultrafiltration Size exclusion chromatography	Extracellular vesicles	Small EVs
1763	Vesiclepedia_2521	34315885	Mus musculus	Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease	Kidney epithelial cells	Protein miRNA	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1764	Vesiclepedia_2394	34355211	Homo sapiens	A size-exclusion-based approach for purifying extracellular vesicles from human plasma	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	Small EVs
1765	Vesiclepedia_2039	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1766	Vesiclepedia_1228	26154623	Homo sapiens	Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals	Plasma	Protein	Size exclusion chromatography	Extracellular vesicles	EVs
1767	Vesiclepedia_577	27894104	Homo sapiens	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	Breast cancer cells	Protein	Differential centrifugation Polymer-based precipitation Ultracentrifugation	Extracellular vesicles	EVs
1768	Vesiclepedia_1551	32082513	Homo sapiens	Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles	Liver cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Large EVs
1769	Vesiclepedia_1593	34282141	Homo sapiens	Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9	Cervical cancer cells	Protein	Centrifugal ultrafiltration Immunoaffinity capture	Extracellular vesicles	EVs
1770	Vesiclepedia_3480	31278254	Homo sapiens	Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma	Ascitic fluid	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1771	Vesiclepedia_2125	36482876	Homo sapiens	Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels	Lung cancer cells	Protein	Differential centrifugation Filtration Ultracentrifugation	Small extracellular vesicles	Small EVs
1772	Vesiclepedia_1924	36214496	Mus musculus	Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA	Motor neuron-like cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1773	Vesiclepedia_961	26047123	Bos taurus	Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models.	Bovine milk	miRNA	Differential centrifugation Ultracentrifugation Filtration	Extracellular vesicles	EVs
1774	Vesiclepedia_2576	35136055	Homo sapiens	Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells	Lung cancer cells	Protein	Differential centrifugation Ultracentrifugation	Small extracellular vesicles	Small EVs
1775	Vesiclepedia_2811	34168137	Homo sapiens	Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis	Colorectal cancer cells	Protein	Differential centrifugation OptiPrep density gradient centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1776	Vesiclepedia_2041	36192599	Mus musculus	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1777	Vesiclepedia_1769	35933512	Mus musculus	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis	Vasculature lavage fluid	Protein	Differential centrifugation	Extracellular vesicles	Large EVs
1778	Vesiclepedia_1064	30006486	Homo sapiens	The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells.	Astrocytoma cells	Protein	Filtration Ultracentrifugation Density gradient centrifugation	Extracellular vesicles	EVs
1779	Vesiclepedia_3418	33391636	Homo sapiens	Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus	Embryonic kidney cells	Protein	Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1780	Vesiclepedia_2098	36192599	Homo sapiens	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma	Hepatic stellate cells	Protein	Differential centrifugation	Large extracellular vesicles	Large EVs
1781	Vesiclepedia_1388	33135636	Mus musculus	CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis	Macrophage	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1782	Vesiclepedia_2779	35304471	Homo sapiens	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Bone	Protein	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1783	Vesiclepedia_2908	33732415	Mus musculus	Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway	Lung cancer cells	Protein	Filtration Centrifugal ultrafiltration ExoQuick Kit Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1784	Vesiclepedia_2791	35304471	Mus musculus	Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox	Liver	miRNA	Differential centrifugation Filtration Ultracentrifugation Centrifugal ultrafiltration OptiPrep density gradient centrifugation	Extracellular vesicles	Small EVs
1785	Vesiclepedia_1874	36063142	Homo sapiens	Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL	Colorectal cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1786	Vesiclepedia_1636	29348617	Mus musculus	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures	Neuroblastoma cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1787	Vesiclepedia_3455	31451800	Homo sapiens	Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories	Cardiosphere-derived cells	miRNA	Filtration Centrifugal ultrafiltration	Extracellular vesicles	Small EVs
1788	Vesiclepedia_1989	35915084	Homo sapiens	Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling	Breast cancer cells	Protein	Differential centrifugation Ultracentrifugation	Extracellular vesicles	Small EVs
1789	Vesiclepedia_1164	29904572	Bos taurus	A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow's milk.	Bovine milk	Protein miRNA	Differential centrifugation Density gradient centrifugation	Extracellular vesicles	EVs